2023
How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches
Mineur Y, Picciotto M. How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches. Journal Of Neurochemistry 2023, 167: 3-15. PMID: 37621094, PMCID: PMC10616967, DOI: 10.1111/jnc.15943.Peer-Reviewed Original Research
2021
Convergent Experimental Systems for Dissecting the Neurobiology of Intrusive Thought: A Road Map
Gourley S, Bonci A, Bruchas M, Flagel S, Haber S, Kalivas P, Milton A, Phillips P, Picciotto M, Seamans J. Convergent Experimental Systems for Dissecting the Neurobiology of Intrusive Thought: A Road Map. 2021, 53-76. DOI: 10.7551/mitpress/13875.003.0010.Peer-Reviewed Original ResearchIntrusive thoughtsIntrusive thinkingThought intrusionsKarl FristonMaladaptive behaviorsMost psychiatric disordersBehavioral processesSuch thoughtsUnacceptable behaviorBehavioral mechanismsW. RobbinsFuture researchRecurrent thoughtsDecision makingA. HolmesPsychiatric disordersThoughtFree willC. RobertsThinkingIndividual responsibilityPsychologyFotopoulouBanichNeuroscience
2008
Nicotine-induced plasticity during development: Modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing
Heath CJ, Picciotto MR. Nicotine-induced plasticity during development: Modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing. Neuropharmacology 2008, 56: 254-262. PMID: 18692078, PMCID: PMC2635334, DOI: 10.1016/j.neuropharm.2008.07.020.Peer-Reviewed Original ResearchConceptsDevelopmental nicotine exposureSmoke exposureNicotine exposureEndogenous cholinergic signalingTobacco smoke exposureSensory processingSensory processing deficitsNicotinic acetylcholine receptorsAttention deficit hyperactivity disorderCritical periodDeficit hyperactivity disorderPregnant womenCholinergic systemCholinergic signalingLong-term consequencesEpidemiological studiesAnimal modelsAcetylcholine receptorsSynaptic plasticityNeuropsychiatric conditionsHyperactivity disorderNicotineExposureProcessing deficitsBehavioral processes
2007
It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood
Picciotto MR, Addy NA, Mineur YS, Brunzell DH. It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood. Progress In Neurobiology 2007, 84: 329-342. PMID: 18242816, PMCID: PMC2390914, DOI: 10.1016/j.pneurobio.2007.12.005.Peer-Reviewed Original ResearchConceptsDesensitization of nAChRsNicotinic acetylcholine receptorsNicotine addictionDrug reinforcementAcetylcholine receptorsAntidepressant-like effectsActivation of nAChRsEffects of nicotineNicotine-mediated behaviorsRecent electrophysiological studiesNicotine administrationTobacco smokingAffective modulationNicotine resultsElectrophysiological studiesSmoking behaviorNicotinic agentsReceptor desensitizationDrug rewardBehavioral consequencesAffective behaviorBehavioral processesBehavioral effectsNAChRsDesensitization