2006
Galanin and galanin‐like peptide modulate neurite outgrowth via protein kinase C‐mediated activation of extracellular signal‐related kinase
Hawes JJ, Narasimhaiah R, Picciotto MR. Galanin and galanin‐like peptide modulate neurite outgrowth via protein kinase C‐mediated activation of extracellular signal‐related kinase. European Journal Of Neuroscience 2006, 23: 2937-2946. PMID: 16819983, DOI: 10.1111/j.1460-9568.2006.04828.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell DifferentiationCells, CulturedDose-Response Relationship, DrugDrug InteractionsEmbryo, MammalianEnzyme ActivationEnzyme InhibitorsExtracellular Signal-Regulated MAP KinasesGalaninGalanin-Like PeptideNeuritesNeuronsProtein Kinase CRatsReceptors, GalaninReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStem CellsConceptsGalanin-like peptideProtein kinase CNervous systemNeurite outgrowthAdult hippocampal progenitor cellsAbility of galaninKinase CERK phosphorylationHippocampal progenitor cellsNeuronal cell line PC12Central nervous systemModulates Neurite OutgrowthExtracellular signal-related kinase (ERK) phosphorylationConcentration-dependent mannerNerve injuryNeuropeptide galaninNeurotrophic effectsExtracellular signal-related kinaseReceptor subtypesNovel physiological roleAdult brainGalaninCell line PC12Signal-related kinaseProgenitor cells
2004
Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neurons
Beech RD, Cleary MA, Treloar HB, Eisch AJ, Harrist AV, Zhong W, Greer CA, Duman RS, Picciotto MR. Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neurons. The Journal Of Comparative Neurology 2004, 475: 128-141. PMID: 15176089, DOI: 10.1002/cne.20179.Peer-Reviewed Original ResearchConceptsPG neuronsSubventricular zoneGranule cellsOlfactory bulbMajor neurogenic regionsAdult-generated neuronsSVZ precursor cellsTetracycline transactivatorRostral migratory streamOlfactory bulb interneuronsTransgene expressionPeriglomerular neuronsPeriglomerular cellsNestin promoterTyrosine hydroxylaseAdult brainInterneuronal populationsBulb interneuronsNeurogenic regionsMigratory streamNeuronal precursorsNeuronsUnique subsetPromoter/enhancerPrecursor cells