2020
OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance
Yang Y, Li X, Luan HH, Zhang B, Zhang K, Nam JH, Li Z, Fu M, Munk A, Zhang D, Wang S, Liu Y, Albuquerque JP, Ong Q, Li R, Wang Q, Robert ME, Perry RJ, Chung D, Shulman GI, Yang X. OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 16616-16625. PMID: 32601203, PMCID: PMC7368321, DOI: 10.1073/pnas.1916121117.Peer-Reviewed Original ResearchConceptsRibosomal protein S6 kinase beta-1Macrophage proinflammatory activationGlcNAc signalingProinflammatory activationUnexpected roleWhole-body metabolismNutrient fluxesLipid accumulationImmune cell activationGlcNAcHomeostatic mechanismsMetabolic disturbancesBeta 1Cell activationDiet-induced metabolic dysfunctionDiet-induced obese miceActivationWhole-body insulin resistanceMacrophage inflammationGlcNAcylationOGTPeripheral tissuesPhosphorylationEnhanced inflammationInsulin resistance
2000
Granular Cells as a Marker of Early Amiodarone Hepatotoxicity
Jain D, Bowlus C, Anderson J, Robert M. Granular Cells as a Marker of Early Amiodarone Hepatotoxicity. Journal Of Clinical Gastroenterology 2000, 31: 241-243. PMID: 11034006, DOI: 10.1097/00004836-200010000-00012.Peer-Reviewed Original ResearchConceptsChronic amiodarone useGranular cellsAmiodarone useAcute hepatitisAcute administrationLiver biopsyPathologic findingsIdiosyncratic reactionsAD therapyAmiodarone hepatotoxicityGranular cytoplasmHepatotoxicityClusters of cellsHepatitisMembranous inclusionsCellsBiopsyHistologicTherapyCliniciansLiverMacrophagesAdministrationWeeks