2023
Clinical Data Do Not Reliably Predict Duodenal Histology at Follow-up in Celiac Disease
Patel N, Leffler D, Al-Toma A, Mulder C, Elli L, Gan G, Patil P, Atsawarungruangkit A, Kuijpers K, Del Gobbo A, Goldsmith J, Hintze Z, Pacheco M, Vieth M, Melcher B, Salomao M, Pai R, Hart J, Olivas A, Naini B, Meyerson C, Choi W, Kakar S, Westerhoff M, Cheng J, Gopal P, Hammer S, Prats M, Bronner M, Robert M. Clinical Data Do Not Reliably Predict Duodenal Histology at Follow-up in Celiac Disease. The American Journal Of Surgical Pathology 2023, 48: 212-220. PMID: 37994653, DOI: 10.1097/pas.0000000000002150.Peer-Reviewed Original ResearchIntraepithelial lymphocytesCeliac diseaseClinical dataMarsh scoreMucosal recoveryVillous bluntingDuodenal biopsiesMucosal injuryDiet adherenceGluten-free diet adherenceComplete histologic remissionPersistent mucosal injuryMinority of patientsCeliac disease patientsDuodenal histologyHistologic remissionPathologists' awarenessMucosal statusMucosal healingGastrointestinal pathologistsDisease patientsFollow-upPatient managementEligibility criteriaPatients
2019
Clinical Insignficance of Monoclonal T-Cell Populations and Duodenal Intraepithelial T-Cell Phenotypes in Celiac and Nonceliac Patients
Celli R, Hui P, Triscott H, Bogardus S, Gibson J, Hwang M, Robert ME. Clinical Insignficance of Monoclonal T-Cell Populations and Duodenal Intraepithelial T-Cell Phenotypes in Celiac and Nonceliac Patients. The American Journal Of Surgical Pathology 2019, 43: 151-160. PMID: 30334829, DOI: 10.1097/pas.0000000000001172.Peer-Reviewed Original ResearchConceptsRefractory celiac diseaseT cell populationsMonoclonal T-cell populationRCD IRCD IICeliac diseasePersistent symptomsCD patientsIntraepithelial lymphocytesType II refractory celiac diseaseCD8-positive intraepithelial lymphocytesClonal T-cell populationsT-cell receptor gene rearrangementsAbnormal intraepithelial lymphocytesT-cell phenotypeReceptor gene rearrangementsParaffin-embedded biopsiesParaffin-embedded tissuesCD8 stainingLymphocyte phenotypingNonceliac patientsVillous bluntingDuodenal biopsiesRare conditionSpecialized centers