2002
Calcium-pump inhibitors induce functional surface expression of ΔF508-CFTR protein in cystic fibrosis epithelial cells
Egan ME, Glöckner-Pagel J, Ambrose C, Cahill PA, Pappoe L, Balamuth N, Cho E, Canny S, Wagner CA, Geibel J, Caplan MJ. Calcium-pump inhibitors induce functional surface expression of ΔF508-CFTR protein in cystic fibrosis epithelial cells. Nature Medicine 2002, 8: 485-492. PMID: 11984593, DOI: 10.1038/nm0502-485.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumCalcium pump inhibitorΔF508-CFTR proteinCystic fibrosis epithelial cellsCystic fibrosis transmembrane conductance regulator (CFTR) proteinCystic fibrosis cell lineFunctional surface expressionSurface expressionChaperone activityChaperone proteinsRegulator proteinPlasma membraneCystic fibrosis defectCell surfaceProteinCell linesPotential targetOptimal activityInhibitor thapsigarginEpithelial cellsExpressionCommon mutationsInhibitorsMouse modelReticulum
1992
Modulation of Ion Transport in Cultured Rabbit Tracheal Epithelium by Lipoxygenase Metabolites
Egan M, Wagner M, Zeitlin P, Guggino W. Modulation of Ion Transport in Cultured Rabbit Tracheal Epithelium by Lipoxygenase Metabolites. American Journal Of Respiratory Cell And Molecular Biology 1992, 7: 500-506. PMID: 1419026, DOI: 10.1165/ajrcmb/7.5.500.Peer-Reviewed Original ResearchConceptsNordihydroguaiaretic acidPresence of NDGALipoxygenase pathwayTracheal epithelial cellsLeukotriene releaseUnstimulated culturesEpithelial cellsCultured rabbit tracheal epitheliumMicroM nordihydroguaiaretic acidCultured tracheal epithelial cellsRabbit tracheal epitheliumExogenous LTD4NDGA inhibitionRabbit tracheal epithelial cellsFluid balanceCl(-) secretionLipoxygenase metabolitesAdult rabbitsTracheal epitheliumPrior inhibitionLTD4InhibitionLTC4Tracer flux experimentsCells