1995
CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP
Schwiebert E, Egan M, Hwang T, Fulmer S, Allen S, Cutting G, Guggino W. CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Cell 1995, 81: 1063-1073. PMID: 7541313, DOI: 10.1016/s0092-8674(05)80011-x.Peer-Reviewed Original ResearchConceptsUnknown regulatory mechanismCystic fibrosis transmembrane conductance regulator (CFTR) functionRegulatory mechanismsConductance regulatorCl- secretory pathwaySignaling mechanismShort-circuit current recordingsRegulator functionCFTR functionChloride channelsCellular mechanismsSingle-channel patch-clamp recordingsCFTRCl- channelsEpithelial cellsATPAutocrine mechanismCurrent recordingsORCCPathwayCF airwaysPatch-clamp recordingsCellsMechanismRegulator
1992
Modulation of Ion Transport in Cultured Rabbit Tracheal Epithelium by Lipoxygenase Metabolites
Egan M, Wagner M, Zeitlin P, Guggino W. Modulation of Ion Transport in Cultured Rabbit Tracheal Epithelium by Lipoxygenase Metabolites. American Journal Of Respiratory Cell And Molecular Biology 1992, 7: 500-506. PMID: 1419026, DOI: 10.1165/ajrcmb/7.5.500.Peer-Reviewed Original ResearchConceptsNordihydroguaiaretic acidPresence of NDGALipoxygenase pathwayTracheal epithelial cellsLeukotriene releaseUnstimulated culturesEpithelial cellsCultured rabbit tracheal epitheliumMicroM nordihydroguaiaretic acidCultured tracheal epithelial cellsRabbit tracheal epitheliumExogenous LTD4NDGA inhibitionRabbit tracheal epithelial cellsFluid balanceCl(-) secretionLipoxygenase metabolitesAdult rabbitsTracheal epitheliumPrior inhibitionLTD4InhibitionLTC4Tracer flux experimentsCells