Regulation of substrate utilization and adiposity by Agrp neurons
Cavalcanti-de-Albuquerque JP, Bober J, Zimmer MR, Dietrich MO. Regulation of substrate utilization and adiposity by Agrp neurons. Nature Communications 2019, 10: 311. PMID: 30659173, PMCID: PMC6338802, DOI: 10.1038/s41467-018-08239-x.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAgouti-Related ProteinAnimalsCapsaicinCarbohydrate MetabolismEnergy MetabolismHypothalamusLipogenesisMiceMice, KnockoutNeuronsWeight GainConceptsFat mass accumulationAgRP neuronsPositive energy balanceWhole-body substrate utilizationAgRP neuron activationHypothalamic AgRP neuronsPair-feeding conditionsSubstrate utilizationFatty acid synthaseCaloric ingestionFat utilizationNeuronal mechanismsWeight gainNeuronsMetabolic changesMass accumulationKey enzymeAdiposityAcid synthaseEnergy metabolismNeuron activationLipogenesisActivationCarbohydrate utilizationMetabolic efficiency