The Effect of Gamma-Hydroxybutyric Acid on Naloxone-Precipitated Opiate Withdrawal
Rosen M, Pearsall H, Woods S, Kosten T. The Effect of Gamma-Hydroxybutyric Acid on Naloxone-Precipitated Opiate Withdrawal. Neuropsychopharmacology 1996, 14: 187-193. PMID: 8866702, DOI: 10.1016/0893-133x(95)00087-t.Peer-Reviewed Original ResearchConceptsGamma-hydroxybutyric acidAnti-withdrawal effectSpontaneous opiate withdrawalOpiate withdrawalDouble-blind challengesNaloxone-precipitated opiate withdrawalGHB administrationGHB pretreatmentIntravenous naloxoneGHB effectsBalanced randomizationNaloxoneGABA metaboliteConsecutive daysWithdrawal measuresSignificant attenuationPrior studiesWithdrawalPretreatmentPlaceboMg/70InpatientsLevorphanolAdministration