1998
The effect of lamotrigine on naloxone-precipitated opiate withdrawal
Rosen M, Pearsall H, Kosten T. The effect of lamotrigine on naloxone-precipitated opiate withdrawal. Drug And Alcohol Dependence 1998, 52: 173-176. PMID: 9800147, DOI: 10.1016/s0376-8716(98)00057-x.Peer-Reviewed Original ResearchConceptsOpiate withdrawalEffects of lamotrigineNaloxone-precipitated opiate withdrawalHeroin-dependent subjectsUnderwent withdrawalAllergic rashRelease antagonistLamotrigineNaloxoneWithdrawalSubjectsRashLevorphanolAntagonist
1997
Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients
Rosen M, Pearsall H, Woods S, Kosten T. Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients. Journal Of Substance Use And Addiction Treatment 1997, 14: 149-154. PMID: 9258859, DOI: 10.1016/s0740-5472(96)00157-2.Peer-Reviewed Original Research
1996
A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal
Rosen M, McMahon T, Woods S, Pearsall H, Kosten T. A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal. European Journal Of Pharmacology 1996, 307: 251-257. PMID: 8836612, DOI: 10.1016/0014-2999(96)00249-x.Peer-Reviewed Original ResearchConceptsNaloxone-precipitated opiate withdrawalOpiate withdrawalOpiate-dependent subjectsPre-clinical studiesConsiderable inter-individual variabilityPretreatment 1 hInter-individual variabilityIntramuscular naloxoneDextromethorphanPilot studyWithdrawal measuresPlaceboNaloxoneMethadoneWithdrawalSubjectsDifferent daysRandomized designEffect of clonidine pretreatment on naloxone-precipitated opiate withdrawal.
Rosen M, McMahon T, Hameedi F, Pearsall H, Woods S, Kreek M, Kosten T. Effect of clonidine pretreatment on naloxone-precipitated opiate withdrawal. Journal Of Pharmacology And Experimental Therapeutics 1996, 276: 1128-35. PMID: 8786543.Peer-Reviewed Original ResearchConceptsClonidine pretreatmentOpiate withdrawalAdrenocorticotropic hormone (ACTH) responseDiastolic blood pressureNaloxone-precipitated opiate withdrawalNaloxone challenge testHeroin-dependent subjectsMeasures of withdrawalNasal congestionBlood pressureNew medicationsWithdrawal severityTesting medicationsChallenge testPlasma cortisolHormone responseConsecutive daysPilot studyClonidineMedicationsPositive controlWithdrawalBase linePretreatmentTwo-factor analysisThe Effect of Gamma-Hydroxybutyric Acid on Naloxone-Precipitated Opiate Withdrawal
Rosen M, Pearsall H, Woods S, Kosten T. The Effect of Gamma-Hydroxybutyric Acid on Naloxone-Precipitated Opiate Withdrawal. Neuropsychopharmacology 1996, 14: 187-193. PMID: 8866702, DOI: 10.1016/0893-133x(95)00087-t.Peer-Reviewed Original ResearchConceptsGamma-hydroxybutyric acidAnti-withdrawal effectSpontaneous opiate withdrawalOpiate withdrawalDouble-blind challengesNaloxone-precipitated opiate withdrawalGHB administrationGHB pretreatmentIntravenous naloxoneGHB effectsBalanced randomizationNaloxoneGABA metaboliteConsecutive daysWithdrawal measuresSignificant attenuationPrior studiesWithdrawalPretreatmentPlaceboMg/70InpatientsLevorphanolAdministration
1995
The Severity of Naloxone-Precipitated Opiate Withdrawal Is Attenuated by Felbamate, a Possible Glycine Antagonist
Kosten T, DeCaprio J, Rosen M. The Severity of Naloxone-Precipitated Opiate Withdrawal Is Attenuated by Felbamate, a Possible Glycine Antagonist. Neuropsychopharmacology 1995, 13: 323-333. PMID: 8747757, DOI: 10.1016/0893-133x(95)00065-l.Peer-Reviewed Original ResearchConceptsNaloxone-precipitated opiate withdrawalDose-related mannerOpiate withdrawalWithdrawal severityN-methyl-D-aspartate (NMDA) receptor systemPartial agonistOverall withdrawal severityGlycinergic agentsPenile groomingWithdrawal signsOpiate detoxificationHA-966NMDA antagonistsRostral medullaGlycine antagonistLow dosePotential treatmentPutative antagonistNMDA channelsClinical useReceptor systemAntagonistTeeth chatterD-cycloserineSeverity