2013
Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI
Sander C, Hooker J, Catana C, Normandin M, Alpert N, Knudsen G, Vanduffel W, Rosen B, Mandeville J. Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 11169-11174. PMID: 23723346, PMCID: PMC3703969, DOI: 10.1073/pnas.1220512110.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingDopamine receptor occupancyReceptor occupancyPositron emission tomographyFunctional magnetic resonance imaging measuresDose of racloprideBasal dopamine levelsDopamine-rich striatumInvestigation of neurovascular couplingDomains of spaceAnesthetized nonhuman primatesSimultaneous PET/fMRIDopamine levelsBrain activitySimultaneous neuroimagingBinding potentialBasal gangliaReceptor systemNonhuman primatesPositron emission tomography tracersMagnetic resonance imagingLiterature differencesEmission tomographyMap associationsNeurovascular couplingA receptor-based model for dopamine-induced fMRI signal
Mandeville J, Sander C, Jenkins B, Hooker J, Catana C, Vanduffel W, Alpert N, Rosen B, Normandin M. A receptor-based model for dopamine-induced fMRI signal. NeuroImage 2013, 75: 46-57. PMID: 23466936, PMCID: PMC3683121, DOI: 10.1016/j.neuroimage.2013.02.036.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasal GangliaDopamineDopamine AgonistsDopamine AntagonistsHumansMagnetic Resonance ImagingModels, NeurologicalConceptsDopamine releaseFMRI dataNon-human primatesLevels of dopamine releaseD2-like receptor familyElevated synaptic dopamineSynaptic dopamineAmphetamine stimulationDopaminergic stimulationFMRINeuroimaging techniquesDopamine effectsFMRI modelFMRI signalsDopamineReceptor densityReceptor occupancyBasal gangliaLow dosesHigh dosesPre-clinical dataNeuroadaptationsRacloprideAmphetamineFunction excitation
2011
A linear model for estimation of neurotransmitter response profiles from dynamic PET data
Normandin MD, Schiffer WK, Morris ED. A linear model for estimation of neurotransmitter response profiles from dynamic PET data. NeuroImage 2011, 59: 2689-2699. PMID: 21767654, PMCID: PMC3702051, DOI: 10.1016/j.neuroimage.2011.07.002.Peer-Reviewed Original Research