2022
A multi-pronged investigation of option generation using depression, PET and modafinil
Ang Y, Cusin C, Petibon Y, Dillon D, Breiger M, Belleau E, Normandin M, Schroder H, Boyden S, Hayden E, Levine M, Jahan A, Meyer A, Kang M, Brunner D, Gelda S, Hooker J, Fakhri G, Fava M, Pizzagalli D. A multi-pronged investigation of option generation using depression, PET and modafinil. Brain 2022, 145: 1854-1865. PMID: 35150243, PMCID: PMC9166534, DOI: 10.1093/brain/awab429.Peer-Reviewed Original ResearchConceptsD2/D3 receptor availabilitySelf-generated optionsDepressive disorderDepressed individualsReceptor availabilityDopamine D2/D3 receptor availabilityNon-depressed adultsEffects of modafinilPutamen of patientsAssociated with uniquenessOption generationD2/D3 receptorsDopaminergic activityClinical depressionBinding potentialModafinilHealthy participantsPutamenPlacebo-controlledSamples of healthy peopleDouble-blindDisordersSelf-generationHealthy controlsDopamine
2017
Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation
Kaiser R, Treadway M, Wooten D, Kumar P, Goer F, Murray L, Beltzer M, Pechtel P, Whitton A, Cohen A, Alpert N, Fakhri G, Normandin M, Pizzagalli D. Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation. Cerebral Cortex 2017, 28: 4281-4290. PMID: 29121332, PMCID: PMC6454484, DOI: 10.1093/cercor/bhx281.Peer-Reviewed Original ResearchConceptsDA transporterRL behaviourVentral striatumDA clearanceFunctional connectivityBinding potentialLevel of neurocognitive functioningIncreased intrinsic functional connectivityMulti-modal neuroimaging studiesResting-state functional connectivityPhasic DA activityStriatal DA transporterIntrinsic functional connectivityReinforcement learning behaviorMulti-modal investigationsFrontostriatal circuitsFrontostriatal connectivityFrontostriatal regionsOrbitofrontal cortexDA activityNeuroimaging studiesOrbitofrontal regionsDopamine markersNeurocognitive functionDopamine
2016
Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics
Yoder K, Albrecht D, Dzemidzic M, Normandin M, Federici L, Graves T, Herring C, Hile K, Walters J, Liang T, Plawecki M, O'Connor S, Kareken D. Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics. Drug And Alcohol Dependence 2016, 160: 163-169. PMID: 26832934, PMCID: PMC5074339, DOI: 10.1016/j.drugalcdep.2016.01.001.Peer-Reviewed Original ResearchConceptsSample of social drinkersNontreatment-seeking alcoholicsSocial drinkersVentral striatumDopamine releaseAlcohol intoxicationAlcohol-induced dopamine releaseVoxel-wise binding potentialTarget breath alcohol concentrationEffects of alcohol intoxicationRight ventral striatumInduce dopamine releaseStriatal DA systemIntravenous alcohol infusionAlcohol use disorderResponse to alcoholBreath alcohol concentrationDA responseStriatal dopamineDA systemTarget BrACAlcohol clampUse disorderDependent drinkersAlcohol infusion
2013
Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
Morris ED, Kim SJ, Sullivan JM, Wang S, Normandin MD, Constantinescu CC, Cosgrove KP. Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking. Journal Of Visualized Experiments 2013, 50358. PMID: 23963311, PMCID: PMC4046621, DOI: 10.3791/50358.Peer-Reviewed Original ResearchConceptsStatistical stepsTime-varying parametersTime-varying functionModel parametersSpatial filterDecomposition techniqueKinetic model parametersConventional modelsSpatial noiseFluctuationsNew modelParametersAnalysis techniquesLp-ntPETModelConventional methodsStatistical comparisonMain stepsDynamic PET dataA receptor-based model for dopamine-induced fMRI signal
Mandeville J, Sander C, Jenkins B, Hooker J, Catana C, Vanduffel W, Alpert N, Rosen B, Normandin M. A receptor-based model for dopamine-induced fMRI signal. NeuroImage 2013, 75: 46-57. PMID: 23466936, PMCID: PMC3683121, DOI: 10.1016/j.neuroimage.2013.02.036.Peer-Reviewed Original ResearchConceptsDopamine releaseFMRI dataNon-human primatesLevels of dopamine releaseD2-like receptor familyElevated synaptic dopamineSynaptic dopamineAmphetamine stimulationDopaminergic stimulationFMRINeuroimaging techniquesDopamine effectsFMRI modelFMRI signalsDopamineReceptor densityReceptor occupancyBasal gangliaLow dosesHigh dosesPre-clinical dataNeuroadaptationsRacloprideAmphetamineFunction excitation
2011
A linear model for estimation of neurotransmitter response profiles from dynamic PET data
Normandin MD, Schiffer WK, Morris ED. A linear model for estimation of neurotransmitter response profiles from dynamic PET data. NeuroImage 2011, 59: 2689-2699. PMID: 21767654, PMCID: PMC3702051, DOI: 10.1016/j.neuroimage.2011.07.002.Peer-Reviewed Original ResearchImaging of alcohol‐induced dopamine release in rats:Preliminary findings with [11C]raclopride PET
Sullivan JM, Risacher SL, Normandin MD, Yoder KK, Froehlich JC, Morris ED. Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [11C]raclopride PET. Synapse 2011, 65: 929-937. PMID: 21308803, PMCID: PMC3130821, DOI: 10.1002/syn.20921.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBlood alcohol concentrationSmall animal positron emission tomographyRat striatumAnimal positron emission tomographyP ratsAlcohol-induced dopamine releaseSignificant alcohol-induced decreaseAlcohol-induced decreaseBlood alcohol levelsLateral saphenous veinAlcohol-preferring ratsAnimals 10 minSystemic alcoholDA releaseMicrodialysis studyStriatal dopamineAlcohol administrationSaphenous veinMale WistarDopamine releaseLarge cohortExtracellular dopamineBlood samplesReceptor availability
2010
Noninvasive visualization of human dopamine dynamics from PET images
Morris ED, Constantinescu CC, Sullivan JM, Normandin MD, Christopher LA. Noninvasive visualization of human dopamine dynamics from PET images. NeuroImage 2010, 51: 135-144. PMID: 20056162, PMCID: PMC3725608, DOI: 10.1016/j.neuroimage.2009.12.082.Peer-Reviewed Original Research
2008
When What You See Isn’t What You Get: Alcohol Cues, Alcohol Administration, Prediction Error, and Human Striatal Dopamine
Yoder KK, Morris ED, Constantinescu CC, Cheng T, Normandin MD, O’Connor S, Kareken DA. When What You See Isn’t What You Get: Alcohol Cues, Alcohol Administration, Prediction Error, and Human Striatal Dopamine. Alcohol Clinical And Experimental Research 2008, 33: 139-149. PMID: 18976347, PMCID: PMC2905874, DOI: 10.1111/j.1530-0277.2008.00821.x.Peer-Reviewed Original ResearchConceptsRinger's lactate infusionAlcohol infusionLactate infusionAlcohol administrationAlcohol-related cuesConditioned cuesStriatal DA concentrationsStriatal DA releaseLactate solutionMesolimbic dopamine systemMidbrain dopamine neuronsRinger's lactate solutionStriatal DAHuman alcohol consumptionDA releaseStriatal dopamineAlcohol drinkingDopamine neuronsDopaminergic responseNeutral cuesBaseline scanHealthy humansPET scansDopamine systemAlcohol consumptionEstimation from PET data of transient changes in dopamine concentration induced by alcohol: support for a non-parametric signal estimation method
Constantinescu C, Yoder K, Kareken D, Bouman C, O'Connor S, Normandin M, Morris E. Estimation from PET data of transient changes in dopamine concentration induced by alcohol: support for a non-parametric signal estimation method. Physics In Medicine And Biology 2008, 53: 1353-1367. PMID: 18296766, DOI: 10.1088/0031-9155/53/5/012.Peer-Reviewed Original ResearchInitial Comparison of ntPET with Microdialysis Measurements of Methamphetamine-Induced Dopamine Release in Rats: Support for Estimation of Dopamine Curves from PET Data
Morris ED, Normandin MD, Schiffer WK. Initial Comparison of ntPET with Microdialysis Measurements of Methamphetamine-Induced Dopamine Release in Rats: Support for Estimation of Dopamine Curves from PET Data. Molecular Imaging And Biology 2008, 10: 67-73. PMID: 18176804, DOI: 10.1007/s11307-007-0124-1.Peer-Reviewed Original Research
2007
Heterogeneous Effects of Alcohol on Dopamine Release in the Striatum: A PET Study
Yoder KK, Constantinescu CC, Kareken DA, Normandin MD, Cheng T, O'Connor SJ, Morris ED. Heterogeneous Effects of Alcohol on Dopamine Release in the Striatum: A PET Study. Alcohol Clinical And Experimental Research 2007, 31: 965-973. PMID: 17428296, DOI: 10.1111/j.1530-0277.2007.00390.x.Peer-Reviewed Original ResearchConceptsAnatomic extentDA responseDA releasePositron emission tomographyAlcohol-related behaviorsDopaminergic responseDopamine releaseD2/D3 receptor availabilityStriatal dopamine releaseHealthy control subjectsStriatal DA responseStriatal binding potentialD3 receptor availabilityTime-Line FollowSubjective responsesVoxel-wise t-testsEffects of alcoholControl subjectsAlcohol infusionPET scansReceptor availabilityEmission tomographyLack of reportsDA involvementPET studies
2006
Temporal Resolution of ntPET Using Either Arterial or Reference Region-Derived Plasma Input Functions
Normandin M, Morris E. Temporal Resolution of ntPET Using Either Arterial or Reference Region-Derived Plasma Input Functions. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2006, 2006: 2005-2008. PMID: 17946491, DOI: 10.1109/iembs.2006.259716.Peer-Reviewed Original Research
2005
ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release
Morris ED, Yoder KK, Wang C, Normandin MD, Zheng QH, Mock B, Raymond F, Froehlich JC. ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release. Molecular Imaging 2005, 4: 7290.2005.05130. PMID: 16285909, DOI: 10.2310/7290.2005.05130.Peer-Reviewed Original ResearchConceptsNeurotransmitter releaseArterial blood samplingEndogenous neurotransmitter releasePositron emission tomographyEndogenous dopamineDrug treatmentRat striatumBlood samplingBlood flowEmission tomographyFalse-positive responsesD3 receptor ligandsDopamine concentrationsPET imagingReceptor ligandsNoninvasive assayTracer kinetic modelReference regionStimulus conditionsDopamine