2020
In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study
Pelletier-Galarneau M, Petibon Y, Ma C, Han P, Kim S, Detmer F, Yokell D, Guehl N, Normandin M, El Fakhri G, Alpert N. In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 414-420. PMID: 32719915, PMCID: PMC7839097, DOI: 10.1007/s00259-020-04878-9.Peer-Reviewed Original ResearchConceptsMembrane potentialBolus injectionHealthy subjectsHematocrit levelsSerial venous blood samplesT1 mapping imagesVenous blood samplesExtracellular space fractionMethodsThirteen healthy subjectsDynamic PET acquisitionCellular membrane potentialGadolinium injectionPrognostic informationVentricular arrhythmiasHeart failureMyocardial hypertrophyMitochondrial membrane potentialCardiac diseaseIn vitro assessmentTherapy monitoringBlood concentrationsPET acquisitionImaging protocolBlood samplesPlasma tracer concentration
2017
Single-scan rest/stress imaging: validation in a porcine model with 18F-Flurpiridaz
Guehl N, Normandin M, Wooten D, Rozen G, Sitek A, Ruskin J, Shoup T, Ptaszek L, El Fakhri G, Alpert N. Single-scan rest/stress imaging: validation in a porcine model with 18F-Flurpiridaz. European Journal Of Nuclear Medicine And Molecular Imaging 2017, 44: 1538-1546. PMID: 28365789, DOI: 10.1007/s00259-017-3684-6.Peer-Reviewed Original ResearchConceptsMyocardial blood flowMicrosphere flow measurementsBlood flowStress myocardial blood flowSingle-scan protocolClinical applicationShort-axis viewMyocardial blood flow measurementsPET dataBlood flow changesIntroduction of adenosineHalf-life of 18FAdenosine infusionRadiotracer injectionAxis viewMyocardial segmentsHealthy pigsClinical translationPET acquisitionTwo-injectionPig modelIschemic areaPorcine modelHalf-lifeAdenosine