In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study
Pelletier-Galarneau M, Petibon Y, Ma C, Han P, Kim S, Detmer F, Yokell D, Guehl N, Normandin M, El Fakhri G, Alpert N. In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 414-420. PMID: 32719915, PMCID: PMC7839097, DOI: 10.1007/s00259-020-04878-9.Peer-Reviewed Original ResearchConceptsMembrane potentialBolus injectionHealthy subjectsHematocrit levelsSerial venous blood samplesT1 mapping imagesVenous blood samplesExtracellular space fractionMethodsThirteen healthy subjectsDynamic PET acquisitionCellular membrane potentialGadolinium injectionPrognostic informationVentricular arrhythmiasHeart failureMyocardial hypertrophyMitochondrial membrane potentialCardiac diseaseIn vitro assessmentTherapy monitoringBlood concentrationsPET acquisitionImaging protocolBlood samplesPlasma tracer concentrationIn-vivo Imaging of Mitochondrial Depolarization of Myocardium With Positron Emission Tomography and a Proton Gradient Uncoupler
Alpert N, Pelletier-Galarneau M, Kim S, Petibon Y, Sun T, Ramos-Torres K, Normandin M, Fakhri G. In-vivo Imaging of Mitochondrial Depolarization of Myocardium With Positron Emission Tomography and a Proton Gradient Uncoupler. Frontiers In Physiology 2020, 11: 491. PMID: 32499721, PMCID: PMC7243673, DOI: 10.3389/fphys.2020.00491.Peer-Reviewed Original ResearchMitochondrial membrane potentialPositron emission tomographyProton gradient uncouplerMembrane potentialIntracoronary infusionEmission tomographyPositron emission tomography scanBolus plus infusionVolume of distributionMitochondrial membraneCellular membrane potentialBAM15InfusionPreliminary dose-response experimentsMaximum depolarizationDose-response experimentsIn vivo imagingSecular equilibrium