2023
Measurement of Cerebral Perfusion Indices from the Early Phase of [18F]MK6240 Dynamic Tau PET Imaging
Guehl N, Dhaynaut M, Hanseeuw B, Moon S, Lois C, Thibault E, Fu J, Price J, Johnson K, El Fakhri G, Normandin M. Measurement of Cerebral Perfusion Indices from the Early Phase of [18F]MK6240 Dynamic Tau PET Imaging. Journal Of Nuclear Medicine 2023, 64: 968-975. PMID: 36997330, PMCID: PMC10241011, DOI: 10.2967/jnumed.122.265072.Peer-Reviewed Original ResearchConceptsTime-activity curvesCerebral perfusionMetabolite-corrected arterial input functionBrain time-activity curvesEarly phaseRegional time-activity curvesIndices of cerebral perfusionDynamic [<sup>18</sup>FBlood-brain barrierPlasma to brain tissueStatistically significant differenceArterial blood samplesForty-nine subjectsCNArterial input functionPathophysiological mechanismsPerfusion indicatorsPET imagingBlood samplesSignificant differenceSurrogate indexNoninvasive estimationAnatomical informationCompound BForty-nine
2020
In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study
Pelletier-Galarneau M, Petibon Y, Ma C, Han P, Kim S, Detmer F, Yokell D, Guehl N, Normandin M, El Fakhri G, Alpert N. In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 414-420. PMID: 32719915, PMCID: PMC7839097, DOI: 10.1007/s00259-020-04878-9.Peer-Reviewed Original ResearchConceptsMembrane potentialBolus injectionHealthy subjectsHematocrit levelsSerial venous blood samplesT1 mapping imagesVenous blood samplesExtracellular space fractionMethodsThirteen healthy subjectsDynamic PET acquisitionCellular membrane potentialGadolinium injectionPrognostic informationVentricular arrhythmiasHeart failureMyocardial hypertrophyMitochondrial membrane potentialCardiac diseaseIn vitro assessmentTherapy monitoringBlood concentrationsPET acquisitionImaging protocolBlood samplesPlasma tracer concentration
2011
Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [11C]raclopride PET
Sullivan JM, Risacher SL, Normandin MD, Yoder KK, Froehlich JC, Morris ED. Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [11C]raclopride PET. Synapse 2011, 65: 929-937. PMID: 21308803, PMCID: PMC3130821, DOI: 10.1002/syn.20921.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBlood alcohol concentrationSmall animal positron emission tomographyRat striatumAnimal positron emission tomographyP ratsAlcohol-induced dopamine releaseSignificant alcohol-induced decreaseAlcohol-induced decreaseBlood alcohol levelsLateral saphenous veinAlcohol-preferring ratsAnimals 10 minSystemic alcoholDA releaseMicrodialysis studyStriatal dopamineAlcohol administrationSaphenous veinMale WistarDopamine releaseLarge cohortExtracellular dopamineBlood samplesReceptor availability