2022
Sex differences and altered mitophagy in experimental pulmonary hypertension
Bazan IS, Kim SJ, Ardito TA, Zhang Y, Shan P, Sauler M, Lee P. Sex differences and altered mitophagy in experimental pulmonary hypertension. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2022, 322: l761-l769. PMID: 35137625, PMCID: PMC9076415, DOI: 10.1152/ajplung.00019.2020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndothelial CellsFemaleHumansHypertension, PulmonaryMaleMiceMitophagySex CharacteristicsUbiquitin-Protein LigasesConceptsPulmonary hypertensionPathogenesis of PHFemale-predominant diseaseRight heart failurePulmonary arterial pressureExperimental pulmonary hypertensionMitochondrial dysfunctionLung endothelial cellsSex differencesMouse lung endothelial cellsInhibition of ParkinArterial pressureHeart failurePulmonary arteryMitochondrial respiratory capacityPoor outcomeHigh prevalenceSevere diseaseAnimal modelsEndothelial cellsParkin expressionOxidative stressCell proliferationHypertensionSexCharacterization of pulmonary vascular remodeling and MicroRNA-126-targets in COPD-pulmonary hypertension
Goel K, Egersdorf N, Gill A, Cao D, Collum S, Jyothula S, Huang H, Sauler M, Lee P, Majka S, Karmouty-Quintana H, Petrache I. Characterization of pulmonary vascular remodeling and MicroRNA-126-targets in COPD-pulmonary hypertension. Respiratory Research 2022, 23: 349. PMID: 36522710, PMCID: PMC9756782, DOI: 10.1186/s12931-022-02267-4.Peer-Reviewed Original ResearchConceptsSmall pulmonary arteriesChronic cigarette smokingPulmonary vascular remodelingPulmonary hypertensionPulmonary arteryLung microvasculatureVascular remodelingEndothelial cellsCOPD-PHMiR126 expressionChronic obstructive pulmonary disease patientsObstructive pulmonary disease patientsCOPD pulmonary hypertensionPulmonary artery sizePulmonary artery remodelingPulmonary disease patientsPulmonary vascular bedPulmonary arterial wallEndothelial cell marker CD31Microvascular endothelial cellsEndothelial cell markersVessel endothelial cellsNon-COPD lungsLarge vessel endothelial cellsArtery remodeling
2021
Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension
Ntokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, Greif DM. Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension. JCI Insight 2021, 6: e139067. PMID: 33591958, PMCID: PMC8026182, DOI: 10.1172/jci.insight.139067.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansHypertension, PulmonaryMacrophagesMiceMuscle, SmoothProto-Oncogene Proteins c-sisConceptsRight ventricle hypertrophyPulmonary hypertensionDistal muscularizationSmooth muscle cellsHypoxia-inducible factor 2APulmonary arterial hypertension patientsLysM-Cre miceArterial hypertension patientsHuman pulmonary hypertensionHypoxia-inducible factor 1aPlatelet-derived growth factorMacrophage-conditioned mediumVentricle hypertrophyHypertension patientsDistal arteriolesMacrophage accumulationFl miceCardiovascular diseaseInterventional strategiesMuscularizationHypoxia exposureExcess macrophagesSMC proliferationLethal diseaseMuscle cells
2013
Standard Nonspecific Therapies in the Management of Pulmonary Arterial Hypertension
Sauler M, Fares WH, Trow TK. Standard Nonspecific Therapies in the Management of Pulmonary Arterial Hypertension. Clinics In Chest Medicine 2013, 34: 799-810. PMID: 24267305, DOI: 10.1016/j.ccm.2013.08.013.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsCalcium Channel BlockersDigoxinDiureticsFamilial Primary Pulmonary HypertensionHumansHypertension, PulmonaryOxygen Inhalation TherapyConceptsHigh-dose calcium channel blockersCommon cardiopulmonary diseasesPAH-specific therapyPulmonary arterial hypertensionTreatment of patientsCalcium channel blockersPAH therapyArterial hypertensionAdjunct therapyOxygen therapyMedical therapyNonspecific therapyCardiopulmonary diseasePathologic understandingChannel blockersSmall studyTherapyHypertension researchExpert opinionAnticoagulationHypertensionDiureticsPatientsBlockersDigoxin