MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis
Yoo SA, Leng L, Kim BJ, Du X, Tilstam PV, Kim KH, Kong JS, Yoon HJ, Liu A, Wang T, Song Y, Sauler M, Bernhagen J, Ritchlin CT, Lee P, Cho CS, Kim WU, Bucala R. MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e7917-e7926. PMID: 27872288, PMCID: PMC5150393, DOI: 10.1073/pnas.1612717113.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorHigh-expression MIF allelesJoint destructionRheumatoid arthritisMIF allelesProgressive joint destructionInvasive phenotypeFibroblast-like synoviocytesMigration inhibitory factorJoint erosionsMIF receptorAutoimmune responseMIF pathwaySynovial fibroblastsCell surface CD74Autocrine pathwayCD44 expressionInhibitory factorPharmacologic inhibitionTumor invasionArthritisInvasive propertiesCD44 receptorCD44Receptor complex