2022
A lung targeted miR-29 mimic as a therapy for pulmonary fibrosis
Chioccioli M, Roy S, Newell R, Pestano L, Dickinson B, Rigby K, Herazo-Maya J, Jenkins G, Ian S, Saini G, Johnson SR, Braybrooke R, Yu G, Sauler M, Ahangari F, Ding S, DeIuliis J, Aurelien N, Montgomery RL, Kaminski N. A lung targeted miR-29 mimic as a therapy for pulmonary fibrosis. EBioMedicine 2022, 85: 104304. PMID: 36265417, PMCID: PMC9587275, DOI: 10.1016/j.ebiom.2022.104304.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisNon-human primatesPulmonary fibrosisAnimal modelsPro-fibrotic genesAnti-fibrotic efficacyMiR-29 mimicsHuman peripheral bloodMiR-29b levelsHuman lung fibroblastsIPF patientsIPF diagnosisPeripheral bloodReduced fibrosisAdverse findingsPotential therapyLung slicesTGF-β1Relevant dosesLung fibroblastsNIH-NHLBIFibrosisTherapyCollagen productionProfibrotic gene program
2021
Nintedanib Inhibits Pulmonary Fibrosis Development in Aged Mice but Does Not Reverse Age-Dependent Established Fibrosis
Kato K, Shin Y, Irish J, Rounseville S, Sauler M, Wollin S, Hecker L. Nintedanib Inhibits Pulmonary Fibrosis Development in Aged Mice but Does Not Reverse Age-Dependent Established Fibrosis. 2021, a4425-a4425. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4425.Peer-Reviewed Original Research
2015
Role of macrophage migration inhibitory factor in age-related lung disease
Sauler M, Bucala R, Lee PJ. Role of macrophage migration inhibitory factor in age-related lung disease. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2015, 309: l1-l10. PMID: 25957294, PMCID: PMC4491511, DOI: 10.1152/ajplung.00339.2014.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMacrophage migration inhibitory factorAge-related lung diseaseMigration inhibitory factorLung diseaseInhibitory factorChronic obstructive lung diseaseChronic lung diseaseObstructive lung diseaseCommon respiratory disorderPulmonary fibrosisClinical manifestationsProinflammatory cytokinesLung cancerRespiratory disordersImmune systemVariant allelesDiseaseHost factorsSuch diseasesPotent upstream regulatorUpstream regulatorPneumoniaFibrosisBody of literatureCytokines