Differential regulation of macrophage activation by the MIF cytokine superfamily members MIF and MIF‐2 in adipose tissue during endotoxemia
Kim B, Tilstam PV, Arnke K, Leng L, Ruhl T, Piecychna M, Schulte W, Sauler M, Frueh FS, Storti G, Lindenblatt N, Giovanoli P, Pallua N, Bernhagen J, Bucala R. Differential regulation of macrophage activation by the MIF cytokine superfamily members MIF and MIF‐2 in adipose tissue during endotoxemia. The FASEB Journal 2020, 34: 4219-4233. PMID: 31961019, PMCID: PMC7060131, DOI: 10.1096/fj.201901511r.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorWhite adipose tissueAdipose tissue macrophagesAdipose tissueElevated macrophage migration inhibitory factorInflammatory cytokine macrophage migration inhibitory factorVisceral white adipose tissueCytokine macrophage migration inhibitory factorPro-inflammatory macrophage polarizationMIF family proteinsPro-inflammatory phenotypeAnti-inflammatory phenotypeMIF-2Migration inhibitory factorWild-type miceHuman adipose tissueMurine endotoxemia modelMIF cytokineMIF deficiencySystemic inflammationDifferential regulationHealthy patientsEndotoxemia modelPeritoneal fluidLeading cause