2016
Integrative Analysis of RNA-Interactome and Translatome Reveal Functional Targets of MSI2 in Myeloid Leukemia
Ramirez O, Kesarwani A, Abhishek G, Minella A, Pillai M. Integrative Analysis of RNA-Interactome and Translatome Reveal Functional Targets of MSI2 in Myeloid Leukemia. Blood 2016, 128: 1881. DOI: 10.1182/blood.v128.22.1881.1881.Peer-Reviewed Original ResearchRNA binding proteinPolysome profilingCell cycle regulatorsTranscription factorsMusashi-2RNA interactomeTarget mRNAsFunctional targetAsymmetric cell divisionSpecific cellular functionsThousands of transcriptsDNA damage responseRBP-RNA complexesMinimal sequence motifSequence-specific fashionPrecise molecular mechanismsTranslational repressionTranslatome profilingCell fateTranslatome analysisCellular functionsSequence motifsDamage responseCell divisionNext-generation sequencing
2011
High Throughput Sequencing Following Cross-Linked Immune Precipitation (HITS-CLIP) of Argonaute (AGO) Identifies Mir-9 As a Regulator of MMP2 in the Marrow Microenvironment (ME)
Balakrishnan I, Yang X, Torok-Storb B, Hesselberth J, Pillai M. High Throughput Sequencing Following Cross-Linked Immune Precipitation (HITS-CLIP) of Argonaute (AGO) Identifies Mir-9 As a Regulator of MMP2 in the Marrow Microenvironment (ME). Blood 2011, 118: 2392. DOI: 10.1182/blood.v118.21.2392.2392.Peer-Reviewed Original ResearchGenome-wide approachesHITS-CLIPMiRNA-mRNA interactomeMiR-9Functional nichesNext-generation sequencingHuman umbilical vein endothelial cellsGene expressionMarrow microenvironmentNew genome-wide approachDirect bindingLuciferase assayMiRNA-based regulationPost-transcriptional regulationCross-species conservationSpecific functional nichesHigh-throughput sequencingMiRNA-mRNA interactionsSmall noncoding RNAsRegulation of hematopoiesisPutative binding sitesStromal cellsCobblestone areaSequence-specific fashionCross-linked RNA