2016
Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas
Toledo RA, Qin Y, Cheng ZM, Gao Q, Iwata S, Silva GM, Prasad M, Ocal IT, Rao S, Aronin N, Barontini M, Bruder J, Reddick RL, Chen Y, Aguiar RC, Dahia PL. Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas. Clinical Cancer Research 2016, 22: 2301-2310. PMID: 26700204, PMCID: PMC4854762, DOI: 10.1158/1078-0432.ccr-15-1841.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenal Gland NeoplasmsAdultAgedC-Mer Tyrosine KinaseCarcinoma, NeuroendocrineChildChromatinChromatin Assembly and DisassemblyExomeFemaleGerm-Line MutationGiant Cell Tumor of BoneHistone DemethylasesHistone MethyltransferasesHistone-Lysine N-MethyltransferaseHistonesHumansMaleMiddle AgedParagangliomaPheochromocytomaThyroid NeoplasmsYoung AdultConceptsHistone methylation analysisAnalysis of mutantsChromatin-remodeling genesChromatin remodelingHistone demethylasesTranscriptome sequencingFrequent genetic eventKinase geneMolecular basisPPGL susceptibility genesGenesGenetic eventsNeural crest originMethylation analysisSusceptibility genesNew cancer syndromeMost PPGLsMutationsSomatic mutationsProtein expressionCell linesDomain mutationsFGFR1 mutationsWestern blottingDriver mutations
2001
Gene expression in papillary thyroid carcinoma reveals highly consistent profiles
Huang Y, Prasad M, Lemon W, Hampel H, Wright F, Kornacker K, LiVolsi V, Frankel W, Kloos R, Eng C, Pellegata N, de la Chapelle A. Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 15044-15049. PMID: 11752453, PMCID: PMC64980, DOI: 10.1073/pnas.251547398.Peer-Reviewed Original ResearchConceptsNumerous additional genesExtracellular matrix proteinsTranscriptase-PCRFunction-related proteinsAdditional genesSpecific molecular changesGene expressionDNA arraysExpression profilesTumor suppressorMatrix proteinsMolecular biologyGenesMolecular pathwaysReverse transcriptase-PCRPTC tissuesCITED1Molecular changesProteinODZ1Concordant expressionHigh expressionNormal thyroid tissueExpressionPapillary thyroid carcinoma