Altered Regulation of Akt Signaling with Murine Cerebral Malaria, Effects on Long-Term Neuro-Cognitive Function, Restoration with Lithium Treatment
Dai M, Freeman B, Shikani HJ, Bruno FP, Collado JE, Macias R, Reznik SE, Davies P, Spray DC, Tanowitz HB, Weiss LM, Desruisseaux MS. Altered Regulation of Akt Signaling with Murine Cerebral Malaria, Effects on Long-Term Neuro-Cognitive Function, Restoration with Lithium Treatment. PLOS ONE 2012, 7: e44117. PMID: 23082110, PMCID: PMC3474787, DOI: 10.1371/journal.pone.0044117.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsChloroquineCognitionFemaleFluorescent Antibody TechniqueGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaImmunoblottingLithiumMalaria, CerebralMiceMice, Inbred C57BLMotor ActivityParasitemiaPhosphorylationProto-Oncogene Proteins c-aktSignal TransductionTau ProteinsConceptsExperimental cerebral malaria modelMotor coordination deficitsAnti-parasitic treatmentChloroquine treatmentCoordination deficitsUninfected controlsLong-term neurological sequelaeCerebral malaria modelCerebral malaria patientsCognitive impairment persistsLong-term neuroMurine cerebral malariaNegative neurological outcomesPbA-infected micePlasmodium berghei ANKABrains of miceP. berghei NK65Adjunctive therapeutic targetManagement of CMAkt activationAkt/GSK3βVisual memory impairmentECM miceNeurological outcomeNeurological sequelae