Response of Adipose Tissue to Early Infection With Trypanosoma cruzi (Brazil Strain)
Nagajyothi F, Desruisseaux MS, Machado FS, Upadhya R, Zhao D, Schwartz GJ, Teixeira MM, Albanese C, Lisanti MP, Chua SC, Weiss LM, Scherer PE, Tanowitz HB. Response of Adipose Tissue to Early Infection With Trypanosoma cruzi (Brazil Strain). The Journal Of Infectious Diseases 2012, 205: 830-840. PMID: 22293433, PMCID: PMC3274374, DOI: 10.1093/infdis/jir840.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdiponectinAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsChagas DiseaseChemokinesCytokinesI-kappa B KinaseMaleMiceMitogen-Activated Protein KinasesNF-kappa BPPAR gammaReceptors, ChemokineRNA, MessengerSignal TransductionToll-Like Receptor 4Toll-Like Receptor 9Trypanosoma cruziConceptsWhite adipose tissueBrown adipose tissueAdipose tissueCruzi infectionNuclear factor kappa B (NF-κB) levelsToll-like receptor 4Peroxisome proliferator-activated receptor γProliferator-activated receptor γMRNA levelsTrypanosoma cruzi infectionMessenger RNA levelsReceptor 4Adipocyte sizeFat massHigher parasite loadsReceptor γEarly infectionExpression of componentsInfectionB levelsLipid accumulationRNA levelsParasite loadEarly targetProtein kinase pathway