2023
A digital health game to prevent opioid misuse and promote mental health in adolescents in school-based health settings: Protocol for the PlaySmart game randomized controlled trial
Boomer T, Hoerner L, Fernandes C, Maslar A, Aiudi S, Kyriakides T, Fiellin L. A digital health game to prevent opioid misuse and promote mental health in adolescents in school-based health settings: Protocol for the PlaySmart game randomized controlled trial. PLOS ONE 2023, 18: e0291298. PMID: 37683047, PMCID: PMC10490848, DOI: 10.1371/journal.pone.0291298.Peer-Reviewed Original ResearchConceptsMental health outcomesOpioid misuseMental healthHealth gamesHealth outcomesMeasures of depressionMental health symptomsGreater riskHelp-seeking behaviorSecondary outcome measuresCritical developmental periodOpioid use disorderPerception of riskRisk of initiationHealth symptomsSchool gradesProfessional helpMisusing opioidsPrimary outcomeDevelopmental periodAdolescentsOutcome measuresSubstance misuseUse disordersHealth settingsMultidisciplinary Strategies for Preventing Opioid Misuse and Escalation by Targeting Mental Health Symptoms and Conditions
Yule A, Fernandes C, Stormshak E, Yang Y, Shelley L, Fiellin L, Larkin K, Ridenour T, Saavedra L, Kelleher K, Feng X, Walton M, Bonar E. Multidisciplinary Strategies for Preventing Opioid Misuse and Escalation by Targeting Mental Health Symptoms and Conditions. Prevention Science 2023, 24: 77-87. PMID: 37266870, PMCID: PMC10236392, DOI: 10.1007/s11121-023-01556-8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnalgesics, OpioidBehavior, AddictiveChildHumansMental HealthOpioid-Related DisordersConceptsMental health conditionsOpioid use disorderOpioid misuseMental health symptomsHealth conditionsHealth symptomsMental healthSubstance useEarly substance usePrevention interventionsHigh riskUse disordersMultidisciplinary strategyPrevention effortsIdentification of youthNational InstituteSymptomsHealthInterventionRiskMisuseAssociationLeveraging the Full Continuum of Care to Prevent Opioid Use Disorder
Cance J, Adams E, D’Amico E, Palimaru A, Fernandes C, Fiellin L, Bonar E, Walton M, Komro K, Knight D, Knight K, Rao V, Youn S, Saavedra L, Ridenour T, Deeds B. Leveraging the Full Continuum of Care to Prevent Opioid Use Disorder. Prevention Science 2023, 24: 30-39. PMID: 37261635, PMCID: PMC10689575, DOI: 10.1007/s11121-023-01545-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnalgesics, OpioidCannabisContinuity of Patient CareHumansOpioid-Related DisordersPrescription Drug MisuseYoung AdultConceptsOpioid use disorderContinuum of careUse disordersPrevention programsDisorder prevention programUnique risk profileOpioid misuseBaseline riskUnique cohortPrevention continuumRisk profileUniversal preventionYoung adultsCareOpioidsOlder adolescentsPreventionDisordersFull continuumMost substancesCohortSubstances
2022
Accelerating Solutions for the Overdose Crisis: an Effectiveness-Implementation Hybrid Protocol for the HEAL Prevention Cooperative
Patel S, Cance J, Bonar E, Carter P, Dickerson D, Fiellin L, Fernandes C, Palimaru A, Boomer T, Saldana L, Singh R, Tinius E, Walton M, Youn S, Young S, Philbrick S, Lambdin B. Accelerating Solutions for the Overdose Crisis: an Effectiveness-Implementation Hybrid Protocol for the HEAL Prevention Cooperative. Prevention Science 2022, 24: 40-49. PMID: 36399222, PMCID: PMC9673891, DOI: 10.1007/s11121-022-01465-2.Peer-Reviewed Original ResearchMethodological Strategies for Prospective Harmonization of Studies: Application to 10 Distinct Outcomes Studies of Preventive Interventions Targeting Opioid Misuse
Ridenour TA, Cruden G, Yang Y, Bonar EE, Rodriguez A, Saavedra LM, Hussong AM, Walton MA, Deeds B, Ford JL, Knight DK, Haggerty KP, Stormshak E, Kominsky TK, Ahrens KR, Woodward D, Feng X, Fiellin LE, Wilens TE, Klein DJ, Fernandes CS. Methodological Strategies for Prospective Harmonization of Studies: Application to 10 Distinct Outcomes Studies of Preventive Interventions Targeting Opioid Misuse. Prevention Science 2022, 24: 16-29. PMID: 35976525, PMCID: PMC9935745, DOI: 10.1007/s11121-022-01412-1.Peer-Reviewed Original Research
2016
Hepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection
Tetrault JM, Tate JP, Edelman EJ, Gordon AJ, Re V, Lim JK, Rimland D, Goulet J, Crystal S, Gaither JR, Gibert CL, Rodriguez-Barradas MC, Fiellin LE, Bryant K, Justice AC, Fiellin DA. Hepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection. Journal Of Substance Use And Addiction Treatment 2016, 68: 62-67. PMID: 27431048, PMCID: PMC4976086, DOI: 10.1016/j.jsat.2016.06.002.Peer-Reviewed Original ResearchConceptsLiver enzyme elevationAlcohol use disorderUninfected patientsHepatotoxic medicationsHCV infectionUse disordersComposite endpointLiver injuryHIV/HCV co-infected patientsHCV co-infected patientsHIV/HCV statusPre-existing liver injuryCo-infected patientsCohort of HIVHepatitis C infectionHIV/HCVOpioid use disorderRisk of hepatotoxicityHCV statusHepatic safetyMedian ALTC infectionChart reviewEnzyme elevationHIV infection
2014
The Impact of Recent Cocaine Use on Plasma Levels of Methadone and Buprenorphine in Patients with and Without HIV-infection
Tetrault JM, McCance-Katz EF, Moody DE, Fiellin DA, Lruie BS, DInh AT, Fiellin LE. The Impact of Recent Cocaine Use on Plasma Levels of Methadone and Buprenorphine in Patients with and Without HIV-infection. Journal Of Substance Use And Addiction Treatment 2014, 51: 70-74. PMID: 25480096, DOI: 10.1016/j.jsat.2014.10.010.Peer-Reviewed Original ResearchConceptsRecent cocaine useHIV infectionCocaine useNorbuprenorphine concentrationsHIV statusBuprenorphine concentrationsS-methadoneAntiretroviral medication useBuprenorphine plasma concentrationsUninfected subjectsMethadone concentrationsMedication usePlasma levelsPlasma concentrationsR-methadoneCocaine effectsClinical careMethadoneBuprenorphineHIVInfectionAbstinenceSubjectsCocaineStatus
2012
Brief versus extended counseling along with buprenorphine/naloxone for HIV-infected opioid dependent patients
Tetrault JM, Moore BA, Barry DT, O'Connor PG, Schottenfeld R, Fiellin DA, Fiellin LE. Brief versus extended counseling along with buprenorphine/naloxone for HIV-infected opioid dependent patients. Journal Of Substance Use And Addiction Treatment 2012, 43: 433-439. PMID: 22938914, DOI: 10.1016/j.jsat.2012.07.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineBuprenorphine, Naloxone Drug CombinationCounselingDelivery of Health Care, IntegratedFeasibility StudiesFemaleFollow-Up StudiesHIV InfectionsHumansMaleMiddle AgedNaloxoneNarcotic AntagonistsOpioid-Related DisordersPsychotherapy, BriefSubstance Abuse DetectionTime FactorsTreatment OutcomeViral LoadConceptsEnhanced medical managementPhysician managementDetectable HIV viral loadHIV treatment settingsOpioid-negative urinesBuprenorphine/naloxoneHIV viral loadOpioid-dependent patientsPercentage of subjectsUntreated opioid dependenceExtended counselingHIV clinicHIV outcomesBuprenorphine/Medical managementOpioid dependenceViral loadDependent patientsExtensive counselingClinical trialsContinuous abstinenceNegative urineTreatment settingsGroup differencesCounselingPrevious Use of Alcohol, Cigarettes, and Marijuana and Subsequent Abuse of Prescription Opioids in Young Adults
Fiellin LE, Tetrault JM, Becker WC, Fiellin DA, Hoff RA. Previous Use of Alcohol, Cigarettes, and Marijuana and Subsequent Abuse of Prescription Opioids in Young Adults. Journal Of Adolescent Health 2012, 52: 158-163. PMID: 23332479, PMCID: PMC3552239, DOI: 10.1016/j.jadohealth.2012.06.010.Peer-Reviewed Original ResearchConceptsPrescription opioidsPrevious marijuana usePrevious substance usePrevious alcoholMarijuana useSubsequent abuseYoung womenSubstance useYoung adulthoodCommunity-dwelling individualsLogistic regression analysisCurrent abusePrevious alcohol useClinical dataOpioidsDrug useSubstance abuseAlcohol useCigarettesPrevention effortsPrevious useYoung adultsYoung individualsYoung menYear olds