Featured Publications
Positive Darwinian selection and the birth of an olfactory receptor clade in teleosts
Hussain A, Saraiva L, Korsching S. Positive Darwinian selection and the birth of an olfactory receptor clade in teleosts. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 4313-4318. PMID: 19237578, PMCID: PMC2657432, DOI: 10.1073/pnas.0803229106.Peer-Reviewed Original ResearchConceptsTrace amine-associated receptorsTAAR genesIntron gainGene familyClass IIIBony fishesOlfactory receptor neuronsPositive Darwinian selectionLocal positive selectionOlfactory receptor gene familyClass III genesOlfactory receptorsOlfactory receptor familyReceptor gene familyOlfactory epitheliumLigand-binding motifsFish genesTeleost lineageReceptor neuronsJawless vertebratesVertebrate evolutionIII genesPositive selectionDarwinian selectionEvolutionary dynamicsA novel olfactory receptor gene family in teleost fish
Saraiva L, Korsching S. A novel olfactory receptor gene family in teleost fish. Genome Research 2007, 17: 1448-1457. PMID: 17717047, PMCID: PMC1987349, DOI: 10.1101/gr.6553207.Peer-Reviewed Original ResearchConceptsOra genesGene pairsMulti-exon structureSpecies-specific expansionOlfactory receptor gene familyV1R-like genesOlfactory receptor familyReceptor gene familySpeciation eventsTeleost lineagePhylogenetic treePhylogenetic analysisGene familyGene regulationGene repertoireGene functionOlfactory epithelium of zebrafishTeleost familiesTeleost speciesOrthologsTeleost fishGenesNegative selectionTeleostFish species
2008
Structural and functional diversification in the teleost S100 family of calcium-binding proteins
Kraemer A, Saraiva L, Korsching S. Structural and functional diversification in the teleost S100 family of calcium-binding proteins. BMC Ecology And Evolution 2008, 8: 48. PMID: 18275604, PMCID: PMC2266712, DOI: 10.1186/1471-2148-8-48.Peer-Reviewed Original ResearchConceptsS100 genesS100 gene familyGene familyJawless fishEF-handPatterns of gene gainCartilaginous fishCalcium-binding proteinLocal gene duplicationS100 familyMammalian family membersCell typesCalcium-mediated signalingEF-hand calcium-binding proteinS100 family membersGenomic arrangementTeleost genomesIntron/exon bordersGene lossGene duplicationGene gainFunctional diversificationS100 subfamilyFamily membersEvolutionary origin