Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms
Gerkin R, Ohla K, Veldhuizen M, Joseph P, Kelly C, Bakke A, Steele K, Farruggia M, Pellegrino R, Pepino M, Bouysset C, Soler G, Pereda-Loth V, Dibattista M, Cooper K, Croijmans I, Di Pizio A, Ozdener M, Fjaeldstad A, Lin C, Sandell M, Singh P, Brindha V, Olsson S, Saraiva L, Ahuja G, Alwashahi M, Bhutani S, D’Errico A, Fornazieri M, Golebiowski J, Hwang L, Öztürk L, Roura E, Spinelli S, Whitcroft K, Faraji F, Fischmeister F, Heinbockel T, Hsieh J, Huart C, Konstantinidis I, Menini A, Morini G, Olofsson J, Philpott C, Pierron D, Shields V, Voznessenskaya V, Albayay J, Altundag A, Bensafi M, Bock M, Calcinoni O, Fredborg W, Laudamiel C, Lim J, Lundström J, Macchi A, Meyer P, Moein S, Santamaría E, Sengupta D, Dominguez P, Yanik H, Hummel T, Hayes J, Reed D, Niv M, Munger S, Parma V, Boesveldt S, de Groot J, Dinnella C, Freiherr J, Laktionova T, Marino S, Monteleone E, Nunez-Parra A, Abdulrahman O, Ritchie M, Thomas-Danguin T, Walsh-Messinger J, Al Abri R, Alizadeh R, Bignon E, Cantone E, Cecchini M, Chen J, Guàrdia M, Hoover K, Karni N, Navarro M, Nolden A, Mazal P, Rowan N, Sarabi-Jamab A, Archer N, Chen B, Di Valerio E, Feeney E, Frasnelli J, Hannum M, Hopkins C, Klein H, Mignot C, Mucignat C, Ning Y, Ozturk E, Peng M, Saatci O, Sell E, Yan C, Alfaro R, Cecchetto C, Coureaud G, Herriman R, Justice J, Kaushik P, Koyama S, Overdevest J, Pirastu N, Ramirez V, Roberts S, Smith B, Cao H, Wang H, Birindwa P, Baguma M. Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms. Chemical Senses 2020, 46: bjaa081. PMID: 33367502, PMCID: PMC7799216, DOI: 10.1093/chemse/bjaa081.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnosmiaCOVID-19Cross-Sectional StudiesFemaleHumansMaleMiddle AgedPrognosisSARS-CoV-2Self ReportSmellConceptsSmell lossOlfactory lossOlfactory recoveryCOVID-19 laboratory test outcomePredictors of COVID-19Visual analog scale ratingsVisual analog scaleC19+Assess symptomsYes/no-questionsRespiratory symptom onsetCardinal symptomsIllnessSymptomsRespiratory illnessBest predictorsC19 groupSymptom onsetParticipantsChemosensory abilitiesIndividualsPredictorsSymptomatic COVID-19Cross-sectional studyAnalog scaleMore Than Smell—COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis
Parma V, Ohla K, Veldhuizen M, Niv M, Kelly C, Bakke A, Cooper K, Bouysset C, Pirastu N, Dibattista M, Kaur R, Liuzza M, Pepino M, Schöpf V, Pereda-Loth V, Olsson S, Gerkin R, Domínguez P, Albayay J, Farruggia M, Bhutani S, Fjaeldstad A, Kumar R, Menini A, Bensafi M, Sandell M, Konstantinidis I, Di Pizio A, Genovese F, Öztürk L, Thomas-Danguin T, Frasnelli J, Boesveldt S, Saatci Ö, Saraiva L, Lin C, Golebiowski J, Hwang L, Ozdener M, Guàrdia M, Laudamiel C, Ritchie M, Havlícek J, Pierron D, Roura E, Navarro M, Nolden A, Lim J, Whitcroft K, Colquitt L, Ferdenzi C, Brindha E, Altundag A, Macchi A, Nunez-Parra A, Patel Z, Fiorucci S, Philpott C, Smith B, Lundström J, Mucignat C, Parker J, van den Brink M, Schmuker M, Fischmeister F, Heinbockel T, Shields V, Faraji F, Santamaría E, Fredborg W, Morini G, Olofsson J, Jalessi M, Karni N, D’Errico A, Alizadeh R, Pellegrino R, Meyer P, Huart C, Chen B, Soler G, Alwashahi M, Welge-Lüssen A, Freiherr J, de Groot J, Klein H, Okamoto M, Singh P, Hsieh J, Reed D, Hummel T, Munger S, Hayes J, Abdulrahman O, Dalton P, Yan C, Voznessenskaya V, Chen J, Sell E, Walsh-Messinger J, Archer N, Koyama S, Deary V, Roberts S, Yanik H, Albayrak S, Nováková L, Croijmans I, Mazal P, Moein S, Margulis E, Mignot C, Mariño S, Georgiev D, Kaushik P, Malnic B, Wang H, Seyed-Allaei S, Yoluk N, Razzaghi-Asl S, Justice J, Restrepo D. More Than Smell—COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis. Chemical Senses 2020, 45: 609-622. PMID: 32564071, PMCID: PMC7337664, DOI: 10.1093/chemse/bjaa041.Peer-Reviewed Original ResearchConceptsChemosensory impairmentSmell lossAssociated with severe impairmentSelf-reported quantityNasal obstructionOlfactory abilityDifference scoresChemosensory modalitiesSevere impairmentPerceived nasal obstructionImpairmentClinical assessment groupClinical assessmentQuality of perceptionLaboratory testsInternational QuestionnaireReduction of smellParticipantsCOVID-19 diagnosisSmellObstructionCOVID-19Assessment Group