Calcium Signaling Regulates Autophagy and Apoptosis
Sukumaran P, Da Conceicao V, Sun Y, Ahamad N, Saraiva L, Selvaraj S, Singh B. Calcium Signaling Regulates Autophagy and Apoptosis. Cells 2021, 10: 2125. PMID: 34440894, PMCID: PMC8394685, DOI: 10.3390/cells10082125.Peer-Reviewed Original ResearchConceptsCell survivalOpposing functionCell death processMaintenance of cellular functionDepletion of Ca<sup>2+</sup>Pathogenesis of neurodegenerative diseasesPromote cell survivalNon-excitable cellsCytosolic Ca<sup>2+</sup> levelsCellular homeostasisCellular functionsAutophagy machineryER storesHuntington's diseaseDiverse functionsDeath processNeuronal developmentFunctional significanceNeurodegenerative diseasesPhysiological functionsNeurodegenerative conditionsApoptosisCellsHomeostasisImmune regulation