2023
Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program.
Yeh H, Peltz-Rauchman C, Johnson C, Pawloski P, Chesla D, Waring S, Stevens A, Epstein M, Joseph C, Miller-Matero L, Gui H, Tang A, Boerwinkle E, Cicek M, Clark C, Cohn E, Gebo K, Loperena R, Mayo K, Mockrin S, Ohno-Machado L, Schully S, Ramirez A, Qian J, Ahmedani B. Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program. PLOS ONE 2023, 18: e0290416. PMID: 37594966, PMCID: PMC10437856, DOI: 10.1371/journal.pone.0290416.Peer-Reviewed Original ResearchConceptsOpioid use disorderOpioid usePrescription opioidsElectronic health recordsReduced oddsDiagnosis of OUDSociodemographic characteristicsPrevalence of OUDNonmedical useLifetime opioid useEHR dataNon-Hispanic white participantsImportant clinical informationNon-medical useLifetime prevalenceStreet opioidsHigher oddsOpioidsClinical informationUse disordersUs Research ProgramSociodemographic correlatesLogistic regressionPrevalenceHealth records
2021
Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project
Karnes J, Arora A, Feng J, Steiner H, Sulieman L, Boerwinkle E, Clark C, Cicek M, Cohn E, Gebo K, Loperena-Cortes R, Ohno-Machado L, Mayo K, Mockrin S, Ramirez A, Schully S, Klimentidis Y. Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project. PLOS ONE 2021, 16: e0255583. PMID: 34358277, PMCID: PMC8345840, DOI: 10.1371/journal.pone.0255583.Peer-Reviewed Original ResearchConceptsBody mass indexBody fat distributionNon-Hispanic blacksNon-Hispanic whitesAlanine aminotransferaseNHB participantsFat distributionAge-adjusted obesity prevalenceNutrition Examination Survey dataBaseline physical examinationRace/ethnicityElectronic health recordsNHB womenWaist circumferenceMass indexHip ratioNHB menPhysical examinationNational HealthObesity prevalenceObesity ratesGender differencesObesityUs Research ProgramNHW participants
2019
Evaluating and sharing global genetic ancestry in biomedical datasets
Harismendy O, Kim J, Xu X, Ohno-Machado L. Evaluating and sharing global genetic ancestry in biomedical datasets. Journal Of The American Medical Informatics Association 2019, 26: 457-461. PMID: 30869786, PMCID: PMC6433181, DOI: 10.1093/jamia/ocy194.Peer-Reviewed Original ResearchConceptsGenetic diversity measurementsGenetic ancestryAvailable molecular datasetsHuman genetics researchCancer Genome Atlas (TCGA) datasetContinental resolutionGenetic diversityPhenotype-genotype associationsMolecular datasetsGlobal genetic ancestryAncestry informationGenetic researchAtlas datasetDiversity measurementsAncestryTraitsGlobal scaleDiversityBiomedical datasetsAvailable datasetsData repositoryDisease riskAccess datasetDatasetAvailable cohorts
2018
Enhancing diversity to reduce health information disparities and build an evidence base for genomic medicine
Hindorff L, Bonham V, Ohno-Machado L. Enhancing diversity to reduce health information disparities and build an evidence base for genomic medicine. Personalized Medicine 2018, 15: 403-412. PMID: 30209973, PMCID: PMC6287493, DOI: 10.2217/pme-2018-0037.Peer-Reviewed Original Research