2011
Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis
Eckert M, Lwin T, Chang A, Kim J, Danis E, Ohno-Machado L, Yang J. Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis. Cancer Cell 2011, 19: 372-386. PMID: 21397860, PMCID: PMC3072410, DOI: 10.1016/j.ccr.2011.01.036.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Vesicular TransportAnimalsBase SequenceBreast NeoplasmsCell LineCell Line, TumorCell MovementCell Surface ExtensionsElectrophoresis, Polyacrylamide GelEpithelial-Mesenchymal TransitionFemaleHEK293 CellsHumansMiceMice, NudeNeoplasm MetastasisNeoplasmsNuclear ProteinsReceptor, Platelet-Derived Growth Factor alphaReverse Transcriptase Polymerase Chain ReactionRNA InterferenceSignal TransductionSrc Homology DomainsTwist-Related Protein 1ConceptsInvadopodia formationTumor metastasisFormation of invadopodiaDirect transcriptional targetTwist1 transcription factorEMT-inducing signalsMatrix degradationPromotes Tumor MetastasisMembrane protrusionsExtracellular matrix degradationTranscriptional targetsTranscription factorsInvadopodiaPDGFRα expressionMesenchymal transitionTwist1Central mediatorPDGFRαKey functions
2008
Peripheral arterial occlusive disease: Global gene expression analyses suggest a major role for immune and inflammatory responses
Fu S, Zhao H, Shi J, Abzhanov A, Crawford K, Ohno-Machado L, Zhou J, Du Y, Kuo W, Zhang J, Jiang M, Jin J. Peripheral arterial occlusive disease: Global gene expression analyses suggest a major role for immune and inflammatory responses. BMC Genomics 2008, 9: 369. PMID: 18673543, PMCID: PMC2529314, DOI: 10.1186/1471-2164-9-369.Peer-Reviewed Original ResearchMeSH KeywordsAdultAtherosclerosisFemoral ArteryGene Expression ProfilingGene Expression RegulationGenes, MHC Class IIHumansInflammationMaleMiddle AgedOligonucleotide Array Sequence AnalysisPeripheral Vascular DiseasesReverse Transcriptase Polymerase Chain ReactionTranscription, GeneticUp-RegulationVasculitisConceptsAdvanced lesionsInflammatory responseDisease progressionArterial diseaseGene OntologyIntermediate lesionsInflammatory genesGenome-wide gene expression profilingReal-time RT-PCR validationGlobal gene expression analysisToll-like receptor signalingBackgroundPeripheral arterial diseaseFemoral artery samplesSignificant cardiovascular morbidityNatural killer cellsFalse discovery rateNormal femoral arteryRT-PCR validationGene expression analysisGene expression profilingAffymetrix microarray platformCardiovascular morbidityKiller cellsFemoral arteryKyoto Encyclopedia