Peripheral arterial occlusive disease: Global gene expression analyses suggest a major role for immune and inflammatory responses
Fu S, Zhao H, Shi J, Abzhanov A, Crawford K, Ohno-Machado L, Zhou J, Du Y, Kuo W, Zhang J, Jiang M, Jin J. Peripheral arterial occlusive disease: Global gene expression analyses suggest a major role for immune and inflammatory responses. BMC Genomics 2008, 9: 369. PMID: 18673543, PMCID: PMC2529314, DOI: 10.1186/1471-2164-9-369.Peer-Reviewed Original ResearchMeSH KeywordsAdultAtherosclerosisFemoral ArteryGene Expression ProfilingGene Expression RegulationGenes, MHC Class IIHumansInflammationMaleMiddle AgedOligonucleotide Array Sequence AnalysisPeripheral Vascular DiseasesReverse Transcriptase Polymerase Chain ReactionTranscription, GeneticUp-RegulationVasculitisConceptsAdvanced lesionsInflammatory responseDisease progressionArterial diseaseGene OntologyIntermediate lesionsInflammatory genesGenome-wide gene expression profilingReal-time RT-PCR validationGlobal gene expression analysisToll-like receptor signalingBackgroundPeripheral arterial diseaseFemoral artery samplesSignificant cardiovascular morbidityNatural killer cellsFalse discovery rateNormal femoral arteryRT-PCR validationGene expression analysisGene expression profilingAffymetrix microarray platformCardiovascular morbidityKiller cellsFemoral arteryKyoto Encyclopedia