2023
A hierarchical strategy to minimize privacy risk when linking “De-identified” data in biomedical research consortia
Ohno-Machado L, Jiang X, Kuo T, Tao S, Chen L, Ram P, Zhang G, Xu H. A hierarchical strategy to minimize privacy risk when linking “De-identified” data in biomedical research consortia. Journal Of Biomedical Informatics 2023, 139: 104322. PMID: 36806328, PMCID: PMC10975485, DOI: 10.1016/j.jbi.2023.104322.Peer-Reviewed Original ResearchConceptsPrivacy of individualsAppropriate privacy protectionData-driven modelsPrivacy protectionPrivacy risksData Coordination CenterData hubData repositoryHierarchical strategyPrivacyBiomedical discoveryData setsRecord linkageData Coordinating CenterRepositoryComplex strategiesCoordination centerTechnologyTechniqueDataPartiesSetHierarchy
2014
A community assessment of privacy preserving techniques for human genomes
Jiang X, Zhao Y, Wang X, Malin B, Wang S, Ohno-Machado L, Tang H. A community assessment of privacy preserving techniques for human genomes. BMC Medical Informatics And Decision Making 2014, 14: s1. PMID: 25521230, PMCID: PMC4290799, DOI: 10.1186/1472-6947-14-s1-s1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBiomedical dataPrivacy preserving techniquesPrivacy protection techniquesData privacyBiomedical computingHuman genomic dataData donorsDissemination techniquesPersonal Genome ProjectRaw dataProtection techniquesRigorous protectionPrivacyGenomic dataFinal resultsComputingCommunity effortsAnalysis outcomesChallengesTechniqueDataProject
2012
Setting Up an Intronic miRNA Database
Hinske L, Heyn J, Galante P, Ohno-Machado L, Kreth S. Setting Up an Intronic miRNA Database. Methods In Molecular Biology 2012, 936: 69-76. PMID: 23007499, DOI: 10.1007/978-1-62703-083-0_5.Peer-Reviewed Original ResearchConceptsAvailable information resourcesWeb-based toolInformation resourcesGenome-wide analysisHost gene transcriptionAnalysis techniquesIntergenic miRNAsIntragenic microRNAsWide analysisUseful analysis techniqueHost genesMiRNA databaseGene transcriptionMiRNA dataDifferent analysis techniquesMiRNAsSignificant attentionTranscriptionDatabaseMore informationRecent pastBasic structureTechniqueUnique linkageGenesPredicting accurate probabilities with a ranking loss.
Menon A, Jiang X, Vembu S, Elkan C, Ohno-Machado L. Predicting accurate probabilities with a ranking loss. Proceedings Of The ... International Conference On Machine Learning. 2012, 2012: 703-710. PMID: 25285328, PMCID: PMC4180410.Peer-Reviewed Original ResearchReal-world applicationsProbability distributionStatistical workhorseIsotonic regressionAccurate probabilityParticular classProbability predictionRegression performanceSemi-parametric techniquesRanking lossRich setBest rankingProbabilityExperimental resultsClassifierApplicationsMachineTechniqueClassSimple technique
2007
10 Generation of knowledge for clinical decision support Statistical and machine learning techniques
Matheny M, Ohno-Machado L. 10 Generation of knowledge for clinical decision support Statistical and machine learning techniques. 2007, 227-248. DOI: 10.1016/b978-012369377-8/50011-8.ChaptersLearning techniquesMedical domainMachine learning techniquesAcceptance of computersClinical decision supportModeling methodAlternative modeling methodDecision supportBiomedical informaticsPopular examplePrediction modelGeneration of knowledgeTheoretical justificationRapid paceRegression techniquesTechnological advancesComputerInformaticsMachineBest modelTechniqueDomainClassificationModelKnowledge
2001
Modeling Medical Prognosis: Survival Analysis Techniques
Ohno-Machado L. Modeling Medical Prognosis: Survival Analysis Techniques. Journal Of Biomedical Informatics 2001, 34: 428-439. PMID: 12198763, DOI: 10.1006/jbin.2002.1038.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements