2018
A Novel Stakeholder Engagement Approach for Patient-centered Outcomes Research
Kim K, Khodyakov D, Marie K, Taras H, Meeker D, Campos H, Ohno-Machado L. A Novel Stakeholder Engagement Approach for Patient-centered Outcomes Research. Medical Care 2018, 56: s41-s47. PMID: 30074950, PMCID: PMC6143220, DOI: 10.1097/mlr.0000000000000790.Peer-Reviewed Original ResearchConceptsClinical Data Research NetworkPatient-centered outcomes researchEngagement of patientsOutcomes research studiesConditions of focusStakeholder advisory boardPatient-centered outcomes research studiesKawasaki diseaseHeart failurePatient advocatesPatientsClinical sitesOutcomes researchSignificant differencesHealth researchCliniciansResearch NetworkResearch prioritiesSetting of prioritiesEngagement strategiesAdvisory BoardFavorable opinionObesityEngagement principlesDisease
2016
Building a Natural Language Processing Tool to Identify Patients With High Clinical Suspicion for Kawasaki Disease from Emergency Department Notes
Doan S, Maehara C, Chaparro J, Lu S, Liu R, Graham A, Berry E, Hsu C, Kanegaye J, Lloyd D, Ohno‐Machado L, Burns J, Tremoulet A, Group T. Building a Natural Language Processing Tool to Identify Patients With High Clinical Suspicion for Kawasaki Disease from Emergency Department Notes. Academic Emergency Medicine 2016, 23: 628-636. PMID: 26826020, PMCID: PMC5031359, DOI: 10.1111/acem.12925.Peer-Reviewed Original ResearchConceptsDiagnosis of KDKawasaki diseaseED notesHigh suspicionPediatric ED patientsSerious cardiac complicationsHigh clinical suspicionEmergency department patientsManual chart reviewCardiac complicationsChart reviewClinical suspicionFebrile illnessDepartment patientsED patientsElectronic health record systemsEmergency departmentClinical signsDiagnostic criteriaHealth record systemsPatientsClinical termsSuspicionDiagnosisRecord system
2014
pSCANNER: patient-centered Scalable National Network for Effectiveness Research
Ohno-Machado L, Agha Z, Bell D, Dahm L, Day M, Doctor J, Gabriel D, Kahlon M, Kim K, Hogarth M, Matheny M, Meeker D, Nebeker J, team T, Resnic F, Khodyakov D, Armstead L, Nagler T, Morley S, Anderson N, Cooper D, Phillips D, Heber D, Li Z, Ong M, Patel A, Zachariah M, Burns J, Daniels L, Doan S, Farcas C, Germann-Kurtz R, Jiang X, Kim H, Paul P, Taras H, Tremoulet A, Wang S, Zhu W, Berman D, Rizk-Jackson A, D’Arcy M, Kesselman C, Knight T, Pearlman L, Heidenreich P, Rifkin D, Stepnowsky C, Zamora T, DuVall S, Frey L, Scehnet J, Sauer B, Facelli J, Gouripeddi R, Denton J, FitzHenry F, Fly J, Messina V, Minter F, Nookala L, Sullivan H, Speroff T, Westerman D. pSCANNER: patient-centered Scalable National Network for Effectiveness Research. Journal Of The American Medical Informatics Association 2014, 21: 621-626. PMID: 24780722, PMCID: PMC4078293, DOI: 10.1136/amiajnl-2014-002751.Peer-Reviewed Original ResearchConceptsInitial use caseCommon data modelPatient Centered Outcomes Research InstituteHealth information exchange dataComputing infrastructuresFederated networkUse casesDistributed systemData modelComputation modelExchange dataPatient-powered research networksCommunity-based outpatient clinicsNetworkCongestive heart failureOutcomes Research InstituteEffectiveness researchAsynchronous modeHealth services researchersKawasaki diseaseHeart failureOutpatient clinicVA InformaticsAmbulatory careNational network
2013
Differential Expression of miR-145 in Children with Kawasaki Disease
Shimizu C, Kim J, Stepanowsky P, Trinh C, Lau H, Akers J, Chen C, Kanegaye J, Tremoulet A, Ohno-Machado L, Burns J. Differential Expression of miR-145 in Children with Kawasaki Disease. PLOS ONE 2013, 8: e58159. PMID: 23483985, PMCID: PMC3590129, DOI: 10.1371/journal.pone.0058159.Peer-Reviewed Original ResearchMeSH KeywordsArteriesBase SequenceChildChild, PreschoolCluster AnalysisGene Expression RegulationHumansInfantMicroRNAsModels, BiologicalMolecular Sequence DataMucocutaneous Lymph Node SyndromeReal-Time Polymerase Chain ReactionSequence AlignmentSequence Analysis, DNASignal TransductionTransforming Growth Factor betaConceptsTGF-β pathwayGene expressionMiR-145Small non-coding RNAsKawasaki disease pathogenesisExtracellular vesiclesSmall RNA speciesPost-transcriptional levelDiscovery of microRNAsKawasaki diseaseNon-coding RNAsExpression of genesDisease pathogenesisSmall extracellular vesiclesSmall RNAsRNA speciesTarget genesTop pathwaysVascular smooth muscle cellsPathway analysisDifferentiation of neutrophilsDifferential expressionMicroRNAsArterial wallGeneration of myofibroblasts