2022
Effect of Obesity on Risk of Hospitalization, Surgery, and Serious Infection in Biologic-Treated Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study
Gu P, Luo J, Kim J, Paul P, Limketkai B, Sauk J, Park S, Parekh N, Zheng K, Rudrapatna V, Syal G, Ha C, McGovern D, Melmed G, Fleshner P, Eisenstein S, Ramamoorthy S, Dulai P, Boland B, Grunvald E, Mahadevan U, Ohno-Machado L, Sandborn W, Singh S. Effect of Obesity on Risk of Hospitalization, Surgery, and Serious Infection in Biologic-Treated Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study. The American Journal Of Gastroenterology 2022, 117: 1639-1647. PMID: 35973139, DOI: 10.14309/ajg.0000000000001855.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseBiologic-treated patientsRisk of hospitalizationBody mass indexNormal body mass indexSerious infectionsBiologic agentsBowel diseaseCox proportional hazards analysisWorld Health Organization classificationEffect of obesityProportional hazards analysisElectronic health recordsCause hospitalizationVisceral obesityAdult patientsBaseline demographicsBiologic initiationBiologic therapyCohort studyEndoscopic outcomesMass indexOrganization classificationTreatment characteristicsStratified analysisSimplified Machine Learning Models Can Accurately Identify High-Need High-Cost Patients With Inflammatory Bowel Disease
Nguyen N, Patel S, Gabunilas J, Qian A, Cecil A, Jairath V, Sandborn W, Ohno-Machado L, Chen P, Singh S. Simplified Machine Learning Models Can Accurately Identify High-Need High-Cost Patients With Inflammatory Bowel Disease. Clinical And Translational Gastroenterology 2022, 13: e00507. PMID: 35905414, PMCID: PMC10476830, DOI: 10.14309/ctg.0000000000000507.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseUnplanned healthcare utilizationAdult patientsBowel diseaseHealthcare utilizationHealthcare costsLogistic regressionRetrospective cohort studyNationwide Readmissions DatabaseIdentification of patientsAdministrative claims dataHigh-cost patientsHNHC patientsCohort studyHospitalized patientsClaims dataHigh riskPatientsTraditional logistic regressionDerivation dataMean AUCIBDMean areaCharacteristic curveDiseaseEffectiveness and Safety of Biologic Therapy in Hispanic Vs Non-Hispanic Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study
Nguyen N, Luo J, Paul P, Kim J, Syal G, Ha C, Rudrapatna V, Park S, Parekh N, Zheng K, Sauk J, Limketkai B, Fleshner P, Eisenstein S, Ramamoorthy S, Melmed G, Dulai P, Boland B, Mahadevan U, Sandborn W, Ohno-Machado L, McGovern D, Singh S. Effectiveness and Safety of Biologic Therapy in Hispanic Vs Non-Hispanic Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study. Clinical Gastroenterology And Hepatology 2022, 21: 173-181.e5. PMID: 35644340, PMCID: PMC9701245, DOI: 10.1016/j.cgh.2022.05.008.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseNon-Hispanic patientsBiologic-treated patientsHispanic patientsSerious infectionsBiologic therapyBowel diseasePropensity score-matched cohortBurden of inflammationRisk of hospitalizationHigh ratePropensity-score matchingCause hospitalizationAdult patientsBiologic initiationCohort studyBiologic agentsMedication useHigh burdenHigh riskHospitalizationPatientsSurvival analysisSurgeryAbstractText
2021
Digital Health Technologies for Remote Monitoring and Management of Inflammatory Bowel Disease: A Systematic Review
Nguyen N, Martinez I, Atreja A, Sitapati A, Sandborn W, Ohno-Machado L, Singh S. Digital Health Technologies for Remote Monitoring and Management of Inflammatory Bowel Disease: A Systematic Review. The American Journal Of Gastroenterology 2021, 117: 78-97. PMID: 34751673, PMCID: PMC8987011, DOI: 10.14309/ajg.0000000000001545.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInflammatory bowel diseaseHealth care utilizationDigital health interventionsRisk of relapseCare utilizationTreatment adherenceHealth interventionsDigital health technologiesSystematic reviewDisease activityBowel diseaseHealth technologiesOverall disease activityDisease activity monitoringManagement of patientsCertainty of evidenceIBD disease activityStandard of careWeb-based interventionHealth care costsPopulation health managementValue-based careRecommendations AssessmentPatients' QoLClinical managementMachine Learning-based Prediction Models for Diagnosis and Prognosis in Inflammatory Bowel Diseases: A Systematic Review
Nguyen N, Picetti D, Dulai P, Jairath V, Sandborn W, Ohno-Machado L, Chen P, Singh S. Machine Learning-based Prediction Models for Diagnosis and Prognosis in Inflammatory Bowel Diseases: A Systematic Review. Journal Of Crohn's And Colitis 2021, 16: 398-413. PMID: 34492100, PMCID: PMC8919806, DOI: 10.1093/ecco-jcc/jjab155.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInflammatory bowel diseaseBowel diseaseClinical dataHigh riskRisk predictionSystematic reviewAcute severe ulcerative colitisLongitudinal disease activitySevere ulcerative colitisAdverse clinical outcomesBias assessment toolRisk of biasAvailable clinical dataMachine learning-based prediction modelsPrediction model RiskDisease activityCohort studyUlcerative colitisClinical outcomesTreatment responseClinical applicabilityLearning-based prediction modelsExternal validationPatientsRisk
2020
National Estimates of Financial Hardship From Medical Bills and Cost-related Medication Nonadherence in Patients With Inflammatory Bowel Diseases in the United States
Nguyen NH, Khera R, Dulai PS, Boland BS, Ohno-Machado L, Sandborn WJ, Singh S. National Estimates of Financial Hardship From Medical Bills and Cost-related Medication Nonadherence in Patients With Inflammatory Bowel Diseases in the United States. Inflammatory Bowel Diseases 2020, 27: 1068-1078. PMID: 33051681, PMCID: PMC8205631, DOI: 10.1093/ibd/izaa266.Peer-Reviewed Original ResearchConceptsCost-related medication nonadherenceInflammatory bowel diseaseBowel diseaseMedication nonadherenceFinancial toxicityMedical billsSelf-reported inflammatory bowel diseaseSubstantial health care needsUnplanned health care utilizationNational estimatesNational Health Interview SurveyHigh ED utilizationEmergency department utilizationHealth care utilizationHealth Interview SurveyTimes higher oddsHealth care needsCost-reducing behaviorsFinancial hardshipValue-based careED utilizationCare utilizationNational burdenHigher oddsHealth care affordabilityBurden and Outcomes of Fragmentation of Care in Hospitalized Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort
Nguyen N, Luo J, Ohno-Machado L, Sandborn W, Singh S. Burden and Outcomes of Fragmentation of Care in Hospitalized Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort. Inflammatory Bowel Diseases 2020, 27: 1026-1034. PMID: 32944753, PMCID: PMC8205632, DOI: 10.1093/ibd/izaa238.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseFragmentation of careHigh riskCohort studyBowel diseaseNationwide Readmissions Database 2013Nationally Representative CohortUS cohort studyRisk of surgeryNumber of patientsRepresentative cohort studyHealth care qualityHospital mortalityHospitalized patientsCohort 2Outpatient careChronic diseasesCohort 1Representative cohortPatientsSingle episodeReadmissionHospitalizationCare qualityCareFrailty Is Independently Associated with Mortality and Readmission in Hospitalized Patients with Inflammatory Bowel Diseases
Qian A, Nguyen N, Elia J, Ohno-Machado L, Sandborn W, Singh S. Frailty Is Independently Associated with Mortality and Readmission in Hospitalized Patients with Inflammatory Bowel Diseases. Clinical Gastroenterology And Hepatology 2020, 19: 2054-2063.e14. PMID: 32801013, PMCID: PMC7930013, DOI: 10.1016/j.cgh.2020.08.010.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseCause of hospitalizationHigh riskFrail patientsBowel diseaseSevere inflammatory bowel diseaseNationwide Readmissions DatabaseRisk of readmissionBurden of hospitalizationRisk of complicationsCost of hospitalizationBenefits of treatmentIndependent effectsRepresentative cohort studyIndex admissionMedian followCause readmissionComorbidity indexIndex hospitalizationCohort studyInpatient mortalityOlder patientsFrailty riskHospitalized patientsLongitudinal burdenPrevalence and Effects of Food Insecurity and Social Support on Financial Toxicity in and Healthcare Use by Patients With Inflammatory Bowel Diseases
Nguyen NH, Khera R, Ohno-Machado L, Sandborn WJ, Singh S. Prevalence and Effects of Food Insecurity and Social Support on Financial Toxicity in and Healthcare Use by Patients With Inflammatory Bowel Diseases. Clinical Gastroenterology And Hepatology 2020, 19: 1377-1386.e5. PMID: 32526341, PMCID: PMC7987215, DOI: 10.1016/j.cgh.2020.05.056.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseEmergency department useCost-related medicationFinancial toxicityBowel diseaseHealthcare useDepartment useSocial supportMedical billsInadequate social supportMultivariable analysisFood insecurityHigh financial toxicityPatientsFinancial hardshipSocial determinantsAbstractTextPopulation healthPrevalenceHealthcare deliveryMedicationsAdultsDiseaseFamily incomeToxicity
2018
Obesity Is Independently Associated With Higher Annual Burden and Costs of Hospitalization in Patients With Inflammatory Bowel Diseases
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Obesity Is Independently Associated With Higher Annual Burden and Costs of Hospitalization in Patients With Inflammatory Bowel Diseases. Clinical Gastroenterology And Hepatology 2018, 17: 709-718.e7. PMID: 30012429, DOI: 10.1016/j.cgh.2018.07.004.Peer-Reviewed Original ResearchConceptsNon-obese patientsInflammatory bowel diseaseNationwide Readmissions Database 2013Cost of hospitalizationBowel diseaseObese patientsAnnual burdenPropensity scoreHospitalization-related costsOutcomes of hospitalizationRepresentative cohort studyHigh-cost patientsCardiopulmonary complicationsIBD patientsAdjunctive therapyCohort studyIBD phenotypePreventable admissionsHigh burdenPatientsHospitalizationObesityAbstractTextObeseInconsistent associationsSu1886 - Burden of Hospitalization and Predictors of High Healthcare Utilization in Patients with Inflammatory Bowel Diseases in the United States
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Su1886 - Burden of Hospitalization and Predictors of High Healthcare Utilization in Patients with Inflammatory Bowel Diseases in the United States. Gastroenterology 2018, 154: s-620. DOI: 10.1016/s0016-5085(18)32232-7.Peer-Reviewed Original ResearchInfections and Cardiovascular Complications are Common Causes for Hospitalization in Older Patients with Inflammatory Bowel Diseases
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Infections and Cardiovascular Complications are Common Causes for Hospitalization in Older Patients with Inflammatory Bowel Diseases. Inflammatory Bowel Diseases 2018, 24: 916-923. PMID: 29562273, DOI: 10.1093/ibd/izx089.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseOlder patientsYounger patientsAnnual burdenNationwide Readmissions Database 2013Treatment-related complicationsDisease-related complicationsCause of hospitalizationRepresentative cohort studyCohort studyBowel diseaseHigh riskPatientsMore daysHospitalizationComplicationsBurdenCauseRehospitalizationHospitalTherapyCohortPrevalenceDiseaseAnnual Burden and Costs of Hospitalization for High-Need, High-Cost Patients With Chronic Gastrointestinal and Liver Diseases
Nguyen NH, Khera R, Ohno-Machado L, Sandborn WJ, Singh S. Annual Burden and Costs of Hospitalization for High-Need, High-Cost Patients With Chronic Gastrointestinal and Liver Diseases. Clinical Gastroenterology And Hepatology 2018, 16: 1284-1292.e30. PMID: 29474966, PMCID: PMC6056327, DOI: 10.1016/j.cgh.2018.02.015.Peer-Reviewed Original ResearchConceptsFunctional gastrointestinal disordersChronic liver diseaseInflammatory bowel diseaseHigh-cost patientsCost of hospitalizationGastrointestinal hemorrhageLiver diseasePancreatic diseaseChronic gastrointestinalHospitalization costsAnnual burdenNationwide Readmissions Database 2013Medicare/Medicaid insuranceHigher comorbidity burdenInfection-related hospitalizationNationwide database analysisMultivariate logistic regressionDays/monthLarge rural hospitalPopulation health managementLow-income statusCardiopulmonary causesComorbidity burdenIndex hospitalizationHigh-value care
2017
Burden, Costs and Causes for Hospitalization in Older Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort Study
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Burden, Costs and Causes for Hospitalization in Older Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort Study. The American Journal Of Gastroenterology 2017, 112: s345. DOI: 10.14309/00000434-201710001-00628.Peer-Reviewed Original ResearchObesity Is Associated With Higher Annual Burden and Costs of Hospitalization in Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort Study
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Obesity Is Associated With Higher Annual Burden and Costs of Hospitalization in Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort Study. The American Journal Of Gastroenterology 2017, 112: s345. DOI: 10.14309/00000434-201710001-00629.Peer-Reviewed Original Research
2009
Evaluation of a large-scale biomedical data annotation initiative
Lacson R, Pitzer E, Hinske C, Galante P, Ohno-Machado L. Evaluation of a large-scale biomedical data annotation initiative. BMC Bioinformatics 2009, 10: s10. PMID: 19761564, PMCID: PMC2745681, DOI: 10.1186/1471-2105-10-s9-s10.Peer-Reviewed Original Research