2008
Intragastric pH With Oral vs Intravenous Bolus Plus Infusion Proton-Pump Inhibitor Therapy in Patients With Bleeding Ulcers
Laine L, Shah A, Bemanian S. Intragastric pH With Oral vs Intravenous Bolus Plus Infusion Proton-Pump Inhibitor Therapy in Patients With Bleeding Ulcers. Gastroenterology 2008, 134: 1836-1841. PMID: 18423628, DOI: 10.1053/j.gastro.2008.03.006.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralDrug Administration ScheduleDuodenal UlcerDuodenoscopyFemaleGastric AcidGastric Acidity DeterminationGastroscopyHumansHydrogen-Ion ConcentrationInfusions, IntravenousMaleMiddle AgedPeptic Ulcer HemorrhageProton Pump InhibitorsStomach UlcerTime FactorsTreatment OutcomeConceptsProton pump inhibitor therapyOral PPIIntravenous PPIInhibitor therapyConfidence intervalsStudy periodFrequent oral dosingHigh-risk stigmataSimilar antisecretory effectIntravenous lansoprazoleOral lansoprazolePPI therapyAntisecretory effectWide confidence intervalsIntragastric pHIntravenous bolusBleeding ulcersOral dosingPatientsBaseline pHUlcersAbstractTextTherapyAIMSBolus
2006
Effect of frequent dosing of an oral proton pump inhibitor on intragastric pH
PAIS SA, NATHWANI RA, DHAR V, NOWAIN A, LAINE L. Effect of frequent dosing of an oral proton pump inhibitor on intragastric pH. Alimentary Pharmacology & Therapeutics 2006, 23: 1607-1613. PMID: 16696810, DOI: 10.1111/j.1365-2036.2006.02933.x.Peer-Reviewed Original ResearchMeSH Keywords2-PyridinylmethylsulfinylbenzimidazolesAdultAnti-Ulcer AgentsGastric Acidity DeterminationHelicobacter pyloriHumansHydrogen-Ion ConcentrationLansoprazoleOmeprazoleProton Pump InhibitorsConceptsProton pump inhibitorsPump inhibitorsOral proton pump inhibitorsDoses of lansoprazoleFrequent oral dosingLansoprazole plasma concentrationHelicobacter pylori statusCYP2C19 statusOral lansoprazolePylori statusOvernight fastOral dosingPlasma concentrationsFrequent dosingHealthy volunteersClot formationTime pointsLansoprazoleMean proportionDosingInhibitorsSubjectsStatusPatientsPeriod
1991
Nosocomial Pneumonia and the Role of Gastric pH A Meta-Analysis
Cook D, Laine L, Guyatt G, Raffin T. Nosocomial Pneumonia and the Role of Gastric pH A Meta-Analysis. CHEST Journal 1991, 100: 7-13. PMID: 1676361, DOI: 10.1378/chest.100.1.7.Peer-Reviewed Original ResearchConceptsStress ulcer prophylaxisUse of sucralfateIncidence of pneumoniaUlcer prophylaxisNosocomial pneumoniaIll patientsGastric pHHistamine-2 receptor antagonistsLarger prospective randomized trialsPercent risk reductionTrial of prophylaxisProspective randomized trialsComputerized bibliographic searchDuplicate independent reviewEffect of antacidIndependent reviewProphylactic therapyRandomized trialsDecreased incidenceControl therapyOdds ratioCommon odds ratioLower incidenceMethodologic deficienciesPneumonia