2021
Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis
Sandborn WJ, Feagan BG, D'Haens G, Wolf DC, Jovanovic I, Hanauer SB, Ghosh S, Petersen A, Hua SY, Lee JH, Charles L, Chitkara D, Usiskin K, Colombel JF, Laine L, Danese S. Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis. New England Journal Of Medicine 2021, 385: 1280-1291. PMID: 34587385, DOI: 10.1056/nejmoa2033617.Peer-Reviewed Original ResearchConceptsActive ulcerative colitisMaintenance therapyUlcerative colitisClinical remissionEnd pointClinical responseCohort 2Cohort 1Selective sphingosine-1-phosphate receptor modulatorSphingosine-1-phosphate receptor modulatorsElevated liver aminotransferase levelsKey secondary end pointLiver aminotransferase levelsPlacebo-controlled trialPrimary end pointSecondary end pointsPercentage of patientsDouble-blind mannerInflammatory bowel diseaseSame daily doseIncidence of infectionHistologic end pointsMayo scoreUnderwent randomizationAminotransferase levels
2020
Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis.
Lee MW, Pourmorady JS, Laine L. Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2020, 115: 662-670. PMID: 31972617, DOI: 10.14309/ajg.0000000000000495.Peer-Reviewed Original ResearchConceptsFecal occult blood testIron deficiency anemiaSensitivity of FOBTAcute diarrheaClinical indicationsSystematic reviewFecal occult blood testingDiagnostic testsSpecific gastrointestinal symptomsOccult blood testingPrimary end pointOccult blood testColorectal cancer screeningPositive stool cultureRisk of biasQUADAS-2 toolGastrointestinal symptomsAdult patientsEndoscopic evaluationUlcerative colitisEndoscopic activityBlood testsIdentifiable causeStool culturesBlood testing
2016
Histological Disease Activity as a Predictor of Clinical Relapse Among Patients With Ulcerative Colitis: Systematic Review and Meta-Analysis
Park S, Abdi T, Gentry M, Laine L. Histological Disease Activity as a Predictor of Clinical Relapse Among Patients With Ulcerative Colitis: Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2016, 111: 1692. PMID: 27725645, DOI: 10.1038/ajg.2016.418.Peer-Reviewed Original ResearchConceptsRelapse/exacerbationHistological remissionEndoscopic remissionClinical remissionHistological activityClinical outcomesUlcerative colitisHistological statusClinical relapseHistological featuresLamina propriaChronic inflammatory cell infiltrateAdditional prognostic utilityHistological disease activityProportion of patientsInflammatory bowel diseaseInflammatory cell infiltrateLack of blindingImproved clinical outcomesDifferent histological featuresSpecific histological featuresRandom-effects modelFixed-effects modelDisease activityUC patientsParadigm Shift in the Surveillance and Management of Dysplasia in Inflammatory Bowel Disease (West)
Soetikno R, Kaltenbach T, McQuaid KR, Subramanian V, Kumar R, Barkun AN, Laine L. Paradigm Shift in the Surveillance and Management of Dysplasia in Inflammatory Bowel Disease (West). Digestive Endoscopy 2016, 28: 266-273. PMID: 26866420, DOI: 10.1111/den.12634.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsManagement of dysplasiaColorectal cancerUlcerative colitisInflammatory bowel disease colitisCrohn's disease (CD) colitisInflammatory bowel diseaseEarly colorectal cancerDysplasia associated lesionHigh-definition colonoscopyInstitute of MedicineNew surveillance paradigmMost dysplasiaColorectal dysplasiaResectable lesionsSurveillance colonoscopyBowel diseaseGRADE methodologyAssociated lesionsTargeted biopsiesConsensus statementHigh riskGeneral populationEndoscopic recognitionGuideline developmentDysplasia
2010
Cytomegalovirus Infection in Patients with Active Inflammatory Bowel Disease
Kim JJ, Simpson N, Klipfel N, DeBose R, Barr N, Laine L. Cytomegalovirus Infection in Patients with Active Inflammatory Bowel Disease. Digestive Diseases And Sciences 2010, 55: 1059-1065. PMID: 20112061, DOI: 10.1007/s10620-010-1126-4.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseActive inflammatory bowel diseaseActive ulcerative colitisUC patientsIndex flareCMV infectionUlcerative colitisCrohn's diseaseCytomegalovirus infectionBowel diseasePrevalence of CMVCourse of diseaseAcute exacerbationIBD colitisUC flareCMV antigensConclusionsThe prevalenceIndex endoscopyMethodsConsecutive patientsClinical courseSevere morbidityClinical featuresImmunohistochemistry stainingGeneral populationPatients