2019
Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn
Spechler SJ, Hunter JG, Jones KM, Lee R, Smith BR, Mashimo H, Sanchez VM, Dunbar KB, Pham TH, Murthy UK, Kim T, Jackson CS, Wallen JM, von Rosenvinge EC, Pearl JP, Laine L, Kim AW, Kaz AM, Tatum RP, Gellad ZF, Lagoo-Deenadayalan S, Rubenstein JH, Ghaferi AA, Lo WK, Fernando RS, Chan BS, Paski SC, Provenzale D, Castell DO, Lieberman D, Souza RF, Chey WD, Warren SR, Davis-Karim A, Melton SD, Genta RM, Serpi T, Biswas K, Huang GD. Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn. New England Journal Of Medicine 2019, 381: 1513-1523. PMID: 31618539, DOI: 10.1056/nejmoa1811424.Peer-Reviewed Original ResearchConceptsPPI-refractory heartburnActive medical treatmentMedical treatmentTreatment successGastroenterology clinicSurgical treatmentProton pump inhibitor treatmentMultichannel intraluminal impedance-pH monitoringMedical groupGastroesophageal reflux diseaseFrequent clinical problemMinority of patientsHealth Related QualityImpedance-pH monitoringMultiple potential causesFunctional heartburnRefractory heartburnVisceral hypersensitivityAntireflux surgeryGastroesophageal refluxReflux diseaseUnderwent endoscopyEsophageal manometryPrimary outcomeEsophageal biopsies
1991
The Causes of Esophageal Symptoms in Human Immunodeficiency Virus Infection: A Prospective Study of 110 Patients
Bonacini M, Young T, Laine L. The Causes of Esophageal Symptoms in Human Immunodeficiency Virus Infection: A Prospective Study of 110 Patients. JAMA Internal Medicine 1991, 151: 1567-1572. DOI: 10.1001/archinte.1991.00400080067012.Peer-Reviewed Original ResearchHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBlind brushingHerpes simplex virusViral cultureHistologic examinationVirus infectionCandida esophagitisEsophageal symptomsSimplex virusViral infectionPositive predictive valueDiagnosis of esophagitisEsophageal infectionsInfectious esophagitisViral esophagitisConsecutive patientsOral thrushOrogastric tubeEsophageal biopsiesProspective studyVirologic testingBiopsy specimensEsophageal brushingsEsophagitisThe causes of esophageal symptoms in human immunodeficiency virus infection. A prospective study of 110 patients.
Bonacini M, Young T, Laine L. The causes of esophageal symptoms in human immunodeficiency virus infection. A prospective study of 110 patients. JAMA Internal Medicine 1991, 151: 1567-72. PMID: 1651690, DOI: 10.1001/archinte.151.8.1567.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBlind brushingHerpes simplex virusViral cultureHistologic examinationVirus infectionCandida esophagitisEsophageal symptomsSimplex virusViral infectionProspective clinical case studyUrban county hospitalPositive predictive valueDiagnosis of esophagitisEsophageal infectionsInfectious esophagitisViral esophagitisConsecutive patientsOral thrushOrogastric tubeEsophageal biopsiesProspective studyVirologic testingBiopsy specimens