Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers: A Systematic Review and Meta-analysis
Sachar H, Vaidya K, Laine L. Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers: A Systematic Review and Meta-analysis. JAMA Internal Medicine 2014, 174: 1755-1762. PMID: 25201154, PMCID: PMC4415726, DOI: 10.1001/jamainternmed.2014.4056.Peer-Reviewed Original ResearchConceptsHigh-risk bleeding ulcersProton pump inhibitorsAbsolute risk differencePPI therapyBleeding ulcersContinuous infusionRisk differenceRisk ratioSystematic reviewDuplicate independent data extractionUrgent interventionRed blood cell transfusionGuideline-recommended regimenReduction of ulcerBlood cell transfusionCochrane Central RegisterControlled Trials databasesTrial of patientsData extractionIndependent data extractionIntravenous bolus doseRandom-effects modelFixed-effects modelPPI dosePPI infusion