2021
Serum Analyte Profiles Associated With Crohn’s Disease and Disease Location
Boucher G, Paradis A, Chabot-Roy G, Coderre L, Hillhouse E, Bitton A, Rosiers C, Levings M, Schumm L, Lazarev M, Brant S, Duerr R, McGovern D, Silverberg M, Cho J, Lesage S, Rioux J, Bitton A, Boucher G, Charron G, Rosiers C, Forest A, Goyette P, Ivinson S, Joseph L, Kohen R, Lachaine J, Lesage S, Levings M, Rioux J, Thompson-Legault J, Vachon L, Veilleux S, White-Guay B, Bajpai M, Birch S, Bitton A, Borowski K, Botwin G, Boucher G, Brant S, Chen W, Cho J, Cordero R, Côté-Daigneault J, Daly M, Datta L, Duerr R, Filice M, Fleshner P, Gettler K, Giri M, Goyette P, Hao K, Haritunians T, Itan Y, Johnston E, Konnikova L, Landers C, Lazarev M, Li D, McGovern D, Mengesha E, Merad M, Miladinova V, Nayeri S, Proksell S, Raquel M, Rioux J, Rymaszewski K, Sabic K, Sands B, Schumm L, Schwartz M, Silverberg M, Simpson C, Stempak J, Stevens C, Targan S, Xavier R. Serum Analyte Profiles Associated With Crohn’s Disease and Disease Location. Inflammatory Bowel Diseases 2021, 28: 9-20. PMID: 34106269, PMCID: PMC8730700, DOI: 10.1093/ibd/izab123.Peer-Reviewed Original ResearchConceptsCrohn's diseaseDisease locationCD patientsIL-6 beingColonic Crohn's diseaseInterleukin IL-6IL-12p70Chronic inflammationColorectal diseaseIL-6Inflammatory processHealthy controlsColorectal regionIntestinal microbiotaClinical observationsEpithelial barrierImmune systemPatientsSerum analytesEndothelial systemDiseaseSerum samplesGrowth factorMultiple cell typesDigestive tract
2018
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis
Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, Horwitz BH, Snapper SB. WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nature Communications 2018, 9: 1779. PMID: 29725003, PMCID: PMC5934380, DOI: 10.1038/s41467-018-03670-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCell DifferentiationColitisGene DeletionGuanine Nucleotide Exchange FactorsHomeostasisHumansImmunity, MucosalInflammationInterleukin-10Interleukin-1betaInterleukin-23Intestinal MucosaMacrophagesMice, Inbred C57BLMice, TransgenicSignal TransductionWiskott-Aldrich SyndromeWiskott-Aldrich Syndrome ProteinConceptsAnti-inflammatory macrophagesMucosal homeostasisMacrophage functionDevelopment of colitisAbsence of WASpColitis developmentAutoimmune sequelaeDendritic cellsIL-10Immune toleranceIntestinal homeostasisWiskott-Aldrich syndrome proteinMacrophagesMacrophage propertiesSTAT3 phosphorylationColitisExpression of WASPWASP deficiencyHomeostasisDOCK8SequelaeMice