CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants
Olaloye OO, Liu P, Toothaker JM, McCourt BT, McCourt CC, Xiao J, Prochaska E, Shaffer S, Werner L, Faculty U, Faculty U, Gringauz J, Good M, Goldsmith JD, An X, Wang F, Snapper SB, Shouval D, Chen K, Tseng G, Konnikova L. CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants. Journal Of Experimental Medicine 2021, 218: e20200344. PMID: 34269788, PMCID: PMC8289692, DOI: 10.1084/jem.20200344.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDAntigens, Differentiation, MyelomonocyticBlood VesselsCase-Control StudiesChemotaxisEnterocolitis, NecrotizingGastric MucosaGPI-Linked ProteinsHumansInfantInfant, NewbornIntestine, SmallMonocytesNeutropeniaNeutrophilsPhagocytosisReactive Oxygen SpeciesReceptors, Cell SurfaceReceptors, IgGSequence Analysis, RNASingle-Cell AnalysisConceptsSurgical NECCirculation of infantsDistinct neutrophil phenotypesSevere gastrointestinal complicationsAreas of inflammationSites of inflammationMonocyte trafficGastrointestinal complicationsPremature infantsNeutrophil phenotypeSevere inflammationInflammatory genesPotential biomarkersSingle-cell RNA sequencingOxygen species generationInflammationNovel subtypeBlood vesselsMass cytometryNECEnterocolitisMucosaInfantsMϕsSpecies generation