Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis
Ashouri JF, Hsu LY, Yu S, Rychkov D, Chen Y, Cheng DA, Sirota M, Hansen E, Lattanza L, Zikherman J, Weiss A. Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 18517-18527. PMID: 31455730, PMCID: PMC6744919, DOI: 10.1073/pnas.1904271116.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsArthritis, ExperimentalArthritis, RheumatoidBiopsyCD4-Positive T-LymphocytesCell DifferentiationDown-RegulationFemaleGenes, ReporterGreen Fluorescent ProteinsHumansInterleukin-17Interleukin-6MaleMiceMice, TransgenicMiddle AgedNuclear Receptor Subfamily 4, Group A, Member 1Receptors, Antigen, T-CellSignal TransductionSuppressor of Cytokine Signaling 3 ProteinSynovectomySynovial MembraneTh17 CellsZymosanConceptsCD4 T cellsRheumatoid arthritisT cellsSKG miceAutoimmune arthritisDifferentiation 4 (CD4) T cellsReceptor signalingHuman autoimmune arthritisIL-6 receptor signalingSKG mouse modelAutoreactive T cellsArthritogenic T cellsIL-6 cytokinesTCR signalingIL-6 signalingRA synoviumSuppressor of cytokineArthritogenic potentialInterleukin-17IL-6Autoantigen exposureEnhanced autoreactivityMouse modelAntigen receptor signalingNur77-eGFP