2001
Natural Antibody Affects Survival of the SpirocheteBorrelia burgdorferi within Feeding Ticks
Belperron A, Bockenstedt L. Natural Antibody Affects Survival of the SpirocheteBorrelia burgdorferi within Feeding Ticks. Infection And Immunity 2001, 69: 6456-6462. PMID: 11553590, PMCID: PMC98781, DOI: 10.1128/iai.69.10.6456-6462.2001.Peer-Reviewed Original ResearchConceptsB cell-deficient miceNatural antibodiesControl miceConfocal immunofluorescence microscopySalivary glandsEarly host defenseBlood-sucking vectorsMammalian hostsFeeding ticksB. burgdorferi organismsNormal mouse serumTick midgutAbsence of exposureOuter surface protein AArthropod vectorsImmunofluorescence microscopyMammalian seraSurface protein ASpirochete Borrelia burgdorferiPolyclonal immunoglobulin MPathogen transmissionSpirochete burdenPassive transferBlood mealImmunoglobulin M
1997
Lyme Borreliosis in Transgenic Mice Tolerant to OspA from Borrelia burgdorferi 25015
Fikrig E, Barthold S, Chen M, Tao H, Ali-Salaam P, Bockenstedt L, Flavell R. Lyme Borreliosis in Transgenic Mice Tolerant to OspA from Borrelia burgdorferi 25015. The Journal Of Infectious Diseases 1997, 175: 1000-1003. PMID: 9086169, DOI: 10.1086/513958.Peer-Reviewed Original ResearchConceptsTransgenic miceLyme borreliosisC3H/HeN miceTolerance of miceSurface protein ABorrelia burgdorferi outer surface protein ASignificant arthritisOuter surface protein ALyme arthritisProtective immunityNontransgenic littermatesHeN miceOspA antibodiesDisease pathogenesisMiceArthritisB. burgdorferi N40OspABorreliosisCellular responsesProtein AResponseImmunizationPathogenesisLittermates