2009
The Caspase 1 Inflammasome Is Not Required for Control of Murine Lyme Borreliosis
Liu N, Belperron AA, Booth CJ, Bockenstedt LK. The Caspase 1 Inflammasome Is Not Required for Control of Murine Lyme Borreliosis. Infection And Immunity 2009, 77: 3320-3327. PMID: 19487481, PMCID: PMC2715671, DOI: 10.1128/iai.00100-09.Peer-Reviewed Original ResearchConceptsCaspase-1 inflammasomeCaspase-1Immune responseHost defenseLyme borreliosisToll-like receptor-mediated responsesDay 14 postinfectionPrevalence of arthritisT cell responsesApoptosis-associated speck-like proteinMild transient elevationBorrelia burgdorferiMurine Lyme borreliosisReceptor-mediated responsesCaspase-1 deficiencyC-terminal caspase recruitment domainSpeck-like proteinAbility of macrophagesEnzyme caspase-1IL-18Humoral immunityInterleukin-1betaTransient elevationPathogen burdenInflammasome
2001
CD4+ T Helper 1 Cells Facilitate Regression of Murine Lyme Carditis
Bockenstedt L, Kang I, Chang C, Persing D, Hayday A, Barthold S. CD4+ T Helper 1 Cells Facilitate Regression of Murine Lyme Carditis. Infection And Immunity 2001, 69: 5264-5269. PMID: 11500394, PMCID: PMC98634, DOI: 10.1128/iai.69.9.5264-5269.2001.Peer-Reviewed Original ResearchConceptsAlphabeta T-cell-deficient miceT cell-deficient miceMurine Lyme carditisT cellsLyme carditisB cellsT helper 1 cellsAnti-inflammatory cytokines mRNA levelsTumor necrosis factor alphaBurgdorferi-specific antibodiesInfected control miceProminent macrophage infiltrateCell-mediated immunityT cell responsesT helper 1Murine Lyme borreliosisCytokine mRNA levelsNecrosis factor alphaAlphabeta T cellsPrincipal immune cellsMouse strain backgroundAdoptive transferAcute arthritisMacrophage infiltratesControl mice