2009
Langerhans Cell Deficiency Impairs Ixodes scapularis Suppression of Th1 Responses in Mice
Vesely DL, Fish D, Shlomchik MJ, Kaplan DH, Bockenstedt LK. Langerhans Cell Deficiency Impairs Ixodes scapularis Suppression of Th1 Responses in Mice. Infection And Immunity 2009, 77: 1881-1887. PMID: 19273564, PMCID: PMC2681756, DOI: 10.1128/iai.00030-09.Peer-Reviewed Original ResearchConceptsTh1 responseTick salivaLangerhans cell subsetsLC-deficient miceSkin dendritic cellsTh1 immune responseTh cell polarizationTh cell responsesRegional lymph nodesT cell responsesTick feedingSecondary lymphoid organsGamma interferon productionSpleens of miceWild-type miceIxodes scapularis ticksT helperDendritic cellsLymph nodesLN cellsCell subsetsImmunomodulatory effectsLymphoid organsTh2 cellsImmune response
2002
Detection of Attenuated, Noninfectious Spirochetes in Borrelia burgdorferi–Infected Mice after Antibiotic Treatment
Bockenstedt LK, Mao J, Hodzic E, Barthold SW, Fish D. Detection of Attenuated, Noninfectious Spirochetes in Borrelia burgdorferi–Infected Mice after Antibiotic Treatment. The Journal Of Infectious Diseases 2002, 186: 1430-1437. PMID: 12404158, DOI: 10.1086/345284.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionSham-treated miceAntibiotic-treated miceBorrelia burgdorferi infectionReal-time polymerase chain reactionIxodes scapularis ticksAntibiotic therapyNaive miceHistopathologic evidenceAntibiotic treatmentBurgdorferi infectionPersistent infectionSpirochete DNAMiceBorrelia burgdorferiMonthsScapularis ticksChain reactionTherapyXenodiagnosisInfectionSpirochetesLimited durationTreatmentLow levels