2007
Marginal Zone B-Cell Depletion Impairs Murine Host Defense against Borrelia burgdorferi Infection
Belperron AA, Dailey CM, Booth CJ, Bockenstedt LK. Marginal Zone B-Cell Depletion Impairs Murine Host Defense against Borrelia burgdorferi Infection. Infection And Immunity 2007, 75: 3354-3360. PMID: 17470546, PMCID: PMC1932939, DOI: 10.1128/iai.00422-07.Peer-Reviewed Original ResearchConceptsT-cell-independent antibodiesCell-depleted miceSplenic CD4Cell depletionPathogen burdenSplenic T cell responsesHost defenseT-cell activation markersC3H/HeJ miceImmunoglobulin M titersInfected control miceMurine host defensePathogen-specific IgMT cell responsesMarginal zone B cellsBlood-borne antigensBlood-borne pathogensWeeks of infectionB cell subsetsImmune mouse serumBorrelia burgdorferi infectionImportant host defenseSevere arthritisActivation markersControl mice
2002
Detection of Attenuated, Noninfectious Spirochetes in Borrelia burgdorferi–Infected Mice after Antibiotic Treatment
Bockenstedt LK, Mao J, Hodzic E, Barthold SW, Fish D. Detection of Attenuated, Noninfectious Spirochetes in Borrelia burgdorferi–Infected Mice after Antibiotic Treatment. The Journal Of Infectious Diseases 2002, 186: 1430-1437. PMID: 12404158, DOI: 10.1086/345284.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionSham-treated miceAntibiotic-treated miceBorrelia burgdorferi infectionReal-time polymerase chain reactionIxodes scapularis ticksAntibiotic therapyNaive miceHistopathologic evidenceAntibiotic treatmentBurgdorferi infectionPersistent infectionSpirochete DNAMiceBorrelia burgdorferiMonthsScapularis ticksChain reactionTherapyXenodiagnosisInfectionSpirochetesLimited durationTreatmentLow levels