2024
Statins Inhibit Cutaneous Squamous Cell Carcinoma Cells
HACKETT A, COHEN A, RUTENBERG T, HODAK E, MOYAL L, ATZMONY L. Statins Inhibit Cutaneous Squamous Cell Carcinoma Cells. Acta Dermato Venereologica 2024, 104: 25097. PMID: 39185545, PMCID: PMC11367778, DOI: 10.2340/actadv.v104.25097.Peer-Reviewed Original Research
2022
Segmental basaloid follicular hamartomas derive from a post‐zygotic SMO p.L412F pathogenic variant and express hair follicle development‐related proteins in a pattern that distinguish them from basal cell carcinomas
Atzmony L, Ugwu N, Bercovitch LG, Robinson‐Bostom L, Ko CJ, Myung P, Choate KA. Segmental basaloid follicular hamartomas derive from a post‐zygotic SMO p.L412F pathogenic variant and express hair follicle development‐related proteins in a pattern that distinguish them from basal cell carcinomas. American Journal Of Medical Genetics Part A 2022, 188: 3525-3530. PMID: 35972041, PMCID: PMC9669121, DOI: 10.1002/ajmg.a.62951.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Basal CellHair FollicleHamartomaHedgehog ProteinsHumansSkin DiseasesSkin NeoplasmsSmoothened ReceptorConceptsBasal cell carcinomaCell carcinomaFollicular hamartomaProliferation indexBasaloid skin tumorsSporadic basal cell carcinomasBasaloid follicular hamartomaKi-67 expressionLow proliferation indexCentral nervous systemWhole-exome sequencingSystemic involvementExpression of hedgehogMultiple lesionsSkin tumorsWnt/beta-catenin pathwayBasaloid lesionsNervous systemVariable involvementPathogenic variantsSegmental distributionPost-zygotic mutational eventSOX-9 expressionNormal tissuesExome sequencingInflammatory linear verrucous epidermal nevus (ILVEN) encompasses a spectrum of inflammatory mosaic disorders
Atzmony L, Ugwu N, Hamilton C, Paller A, Zech L, Antaya R, Choate K. Inflammatory linear verrucous epidermal nevus (ILVEN) encompasses a spectrum of inflammatory mosaic disorders. Pediatric Dermatology 2022, 39: 903-907. PMID: 35853659, PMCID: PMC9712156, DOI: 10.1111/pde.15094.Peer-Reviewed Original ResearchConceptsInflammatory linear verrucous epidermal nevusVerrucous epidermal nevusEpidermal nevusCARD14 mutationsHotspot mutationsLinear verrucous epidermal nevusPathogenesis-directed therapyCohort of patientsErythematous scaly plaquesRare skin diseaseLines of BlaschkoSomatic pathogenic variantsNSDHL mutationsHistopathological evaluationInflammatory disordersScaly plaquesHistopathologic evaluationHistopathological criteriaLinear porokeratosisSkin lesionsAffected skinPatientsSkin diseasesClinical descriptorsHeterogenous group
2020
Post‐zygotic ACTB mutations underlie congenital smooth muscle hamartomas
Atzmony L, Ugwu N, Zaki TD, Antaya RJ, Choate KA. Post‐zygotic ACTB mutations underlie congenital smooth muscle hamartomas. Journal Of Cutaneous Pathology 2020, 47: 681-685. PMID: 32170967, PMCID: PMC7943230, DOI: 10.1111/cup.13683.Peer-Reviewed Original ResearchConceptsCongenital smooth muscle hamartomaSmooth muscle hamartomaBecker's nevusMuscle hamartomaBecker nevus syndromeDirect sequencingHistopathological featuresHistopathological overlapBenign lesionsMosaic disordersPhenotypic spectrumNeviUnaffected tissueAffected tissuesHamartomaPost-zygotic mutationsHemihypertrophyEnrichment assayTissueMutationsACTB geneMutations in KRT10 in epidermolytic acanthoma
Cheraghlou S, Atzmony L, Roy SF, McNiff JM, Choate KA. Mutations in KRT10 in epidermolytic acanthoma. Journal Of Cutaneous Pathology 2020, 47: 524-529. PMID: 32045015, PMCID: PMC7914398, DOI: 10.1111/cup.13664.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingEpidermolytic acanthomaEpidermolytic hyperkeratosisHotspot mutationsCharacteristic histopathological patternEpidermolytic ichthyosisHistopathological patternsHistopathological analysisDiscovery cohortLesional tissueAdditional casesPolymerase chain reaction amplificationEpidermal degenerationChain reaction amplificationFragment length polymorphism analysisRestriction fragment length polymorphism analysisLength polymorphism analysisDermatosesIchthyosis bullosaAcanthomaKRT10Departmental archivesReaction amplificationIchthyosisPolymorphism analysisStage-dependent Increase in Expression of miR-155 and Ki-67 and Number of Tumour-associated Inflammatory Cells in Folliculotropic Mycosis Fungoides
ATZMONY L, MOYAL L, FEINMESSER M, GOROVITZ B, HIRSHBERG A, AMITAY-LAISH I, PRAG-NAVEH H, BARZILAI A, HODAK E. Stage-dependent Increase in Expression of miR-155 and Ki-67 and Number of Tumour-associated Inflammatory Cells in Folliculotropic Mycosis Fungoides. Acta Dermato Venereologica 2020, 100: 5828. PMID: 32556361, PMCID: PMC9207631, DOI: 10.2340/00015555-3578.Peer-Reviewed Original ResearchConceptsFolliculotropic mycosis fungoidesMycosis fungoidesKi-67Inflammatory cellsCD20+ B cellsTumor-associated inflammatory cellsTumor-infiltrating inflammatory cellsVariant of mycosis fungoidesEarly-stage MFTumour cell immunoreactivityCD68+ macrophagesMiR-155 expressionTumor-stage MFStage-dependent increaseStatistically significant differenceIndolent stageMiR-155Clinicopathological stageCell immunoreactivityB cellsInflammatory dermatosesImmunohistochemical analysisProliferating lymphocytesFungoidesSignificant difference
2017
Trends in the Mohs Surgery Literature
Kershenovich R, Atzmony L, Reiter O, Lapidoth M, Mimouni D. Trends in the Mohs Surgery Literature. Dermatologic Surgery 2017, 43: 876-880. PMID: 28195847, DOI: 10.1097/dss.0000000000001061.Peer-Reviewed Original Research
2016
New insights into folliculotropic mycosis fungoides (FMF): A single-center experience
Hodak E, Amitay-Laish I, Atzmony L, Prag-Naveh H, Yanichkin N, Barzilai A, Kershenovich R, Feinmesser M. New insights into folliculotropic mycosis fungoides (FMF): A single-center experience. Journal Of The American Academy Of Dermatology 2016, 75: 347-355. PMID: 27245278, DOI: 10.1016/j.jaad.2016.03.009.Peer-Reviewed Original ResearchConceptsFolliculotropic mycosis fungoidesMycosis fungoidesPattern of clinicopathological featuresAdvanced stageLong-term follow-upLack of long-term follow-upTertiary medical centerEarly-stage lesionsEarly-stage groupPresence of eosinophilsAggressive courseTumor stageClinicopathological presentationHistopathological discriminationPerifollicular infiltratePrognostic implicationsClinicopathological featuresInfiltration densityAcneiform lesionsClinical manifestationsIndurated plaquesFollow-upMultivariate analysisTumorMedical Center