2019
Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc
Li M, Lazorchak AS, Ouyang X, Zhang H, Liu H, Arojo OA, Yan L, Jin J, Han Y, Qu G, Fu Y, Xu X, Liu X, Zhang W, Yang Z, Ruan C, Wang Q, Liu D, Huang C, Lu L, Jiang S, Li F, Su B. Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc. Cellular & Molecular Immunology 2019, 16: 757-769. PMID: 30705387, PMCID: PMC6804816, DOI: 10.1038/s41423-018-0185-x.Peer-Reviewed Original ResearchConceptsCell growthActivation of mTORC2MTOR complex 2B cell growthAkt-dependent inactivationC-myc proteinMolecular mechanismsSIN1Molecular levelGenetic ablationB cell-mediated immunitySpecific roleCell sizeMetabolismB cell proliferationComplexes 2GrowthAnti-viral immunityMTORC2GSK3B cellsMYCKey componentProteinTransitional stage
2018
Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
Wu ZR, Yan L, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B, Wu ZB. Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours. Nature Communications 2018, 9: 4624. PMID: 30397197, PMCID: PMC6218470, DOI: 10.1038/s41467-018-06853-3.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCabergolineCarcinogenesisCarrier ProteinsCell Cycle ProteinsCell Line, TumorCell ProliferationDisease ProgressionDown-RegulationFemaleHEK293 CellsHeterograftsHumansMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2MicePhosphoproteinsPhosphorylationPituitary NeoplasmsRibosomal Protein S6 Kinases, 70-kDaRNA, Long NoncodingUp-RegulationConceptsPituitary tumorsTumor growthTumor progressionLong noncoding RNA H19Potential therapeutic targetTumor growth regulationHuman pituitary tumorsFunction of H19Pituitary tumor cell proliferationTumor cell proliferationPrimary pituitary adenomaCabergoline treatmentPituitary adenomasTherapeutic targetInhibition of mTORC1RNA H19LncRNA H19H19 expressionAberrant expressionTumorsCell proliferationProgressionH19Growth regulationAdenomas