Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets
Xu Y, Ouyang X, Yan L, Zhang M, Hu Z, Gu J, Fan X, Zhang L, Zhang J, Xue S, Chen G, Su B, Liu J. Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets. Arteriosclerosis Thrombosis And Vascular Biology 2018, 38: 1. PMID: 30571167, DOI: 10.1161/atvbaha.118.311822.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdultAgedAged, 80 and overAnimalsBlood PlateletsCarrier ProteinsCell HypoxiaDisease Models, AnimalFemaleHumansMaleMechanistic Target of Rapamycin Complex 2Mice, Inbred C57BLMice, KnockoutMiddle AgedMyocardial InfarctionPhosphorylationPlatelet ActivationPlatelet Glycoprotein GPIIb-IIIa ComplexProto-Oncogene Proteins c-aktReactive Oxygen SpeciesSignal TransductionSirtuin 3Superoxide DismutaseThrombosisConceptsOxygen speciesTarget AktSIN1Reactive oxygen speciesHypoxia responseNovel roleMyocardial infarctionIntegrin αIIbβ3Downstream signalsValuable therapeutic targetCell proliferationAktDeficiency micePhosphorylationST-segment elevation myocardial infarctionPlatelet activationLeft anterior descending (LAD) obstructionPump coronary artery bypassSignalingSpeciesTherapeutic targetΑIIbβ3Coronary artery bypassInhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
Wu ZR, Yan L, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B, Wu ZB. Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours. Nature Communications 2018, 9: 4624. PMID: 30397197, PMCID: PMC6218470, DOI: 10.1038/s41467-018-06853-3.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCabergolineCarcinogenesisCarrier ProteinsCell Cycle ProteinsCell Line, TumorCell ProliferationDisease ProgressionDown-RegulationFemaleHEK293 CellsHeterograftsHumansMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2MicePhosphoproteinsPhosphorylationPituitary NeoplasmsRibosomal Protein S6 Kinases, 70-kDaRNA, Long NoncodingUp-RegulationConceptsPituitary tumorsTumor growthTumor progressionLong noncoding RNA H19Potential therapeutic targetTumor growth regulationHuman pituitary tumorsFunction of H19Pituitary tumor cell proliferationTumor cell proliferationPrimary pituitary adenomaCabergoline treatmentPituitary adenomasTherapeutic targetInhibition of mTORC1RNA H19LncRNA H19H19 expressionAberrant expressionTumorsCell proliferationProgressionH19Growth regulationAdenomas