2022
Brainstem serotonin neurons selectively gate retinal information flow to thalamus
Reggiani J, Jiang Q, Barbini M, Lutas A, Liang L, Fernando J, Deng F, Wan J, Li Y, Chen C, Andermann M. Brainstem serotonin neurons selectively gate retinal information flow to thalamus. Neuron 2022, 111: 711-726.e11. PMID: 36584680, PMCID: PMC10131437, DOI: 10.1016/j.neuron.2022.12.006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCalciumGeniculate BodiesMiceReceptor, Serotonin, 5-HT1BRetinal Ganglion CellsSerotoninThalamusConceptsVisual information streamsRetinal ganglion cell typesBrainstem serotonin neuronsFiber photometry recordingsGanglion cell typesTwo-photon calcium imagingSerotonin neuronsVisual thalamusGlutamate releaseSerotonergic axonsRGC axonsSerotonin axonsThalamocortical neuronsAxon stimulationAwake micePresynaptic terminalsCalcium imagingOptogenetic stimulationCalcium activityLocal visual stimuliAxonsThalamusBoutonsVisual stimuliNeurons
2020
Organization, Function, and Development of the Mouse Retinogeniculate Synapse
Liang L, Chen C. Organization, Function, and Development of the Mouse Retinogeniculate Synapse. Annual Review Of Vision Science 2020, 6: 261-285. PMID: 32936733, DOI: 10.1146/annurev-vision-121219-081753.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsGeniculate BodiesHumansMiceRetinal Ganglion CellsSynaptic TransmissionThalamusVisual PathwaysConceptsRetinogeniculate synapseDistinct retinal ganglion cell typesRetinal ganglion cell typesGanglion cell typesImage-forming pathwayVisual thalamusThalamocortical neuronsVisual pathwayExperimental modelCircuit organizationThalamusSynapseMiceCell typesFunctional organizationRecent studiesPowerful experimental modelCurrent understandingVisual spaceVisual experiencePathwayNeuronsRGCs
2018
A Fine-Scale Functional Logic to Convergence from Retina to Thalamus
Liang L, Fratzl A, Goldey G, Ramesh RN, Sugden AU, Morgan JL, Chen C, Andermann ML. A Fine-Scale Functional Logic to Convergence from Retina to Thalamus. Cell 2018, 173: 1343-1355.e24. PMID: 29856953, PMCID: PMC6003778, DOI: 10.1016/j.cell.2018.04.041.Peer-Reviewed Original ResearchConceptsAxonal boutonsRetinal ganglion cellsTwo-photon calciumImage-forming visionClusters of boutonsVisual thalamusGanglion cellsRetinal axonsBouton clustersThalamusMouse thalamusIndividual axonsDifferent axonsFeature selectivityBoutonsFine-scale organizationAxonsDendritic domainsUltrastructural analysisRetina