2018
Actin and myosin II modulate differentiation of pluripotent stem cells
Boraas L, Pineda E, Ahsan T. Actin and myosin II modulate differentiation of pluripotent stem cells. PLOS ONE 2018, 13: e0195588. PMID: 29664925, PMCID: PMC5903644, DOI: 10.1371/journal.pone.0195588.Peer-Reviewed Original ResearchConceptsPluripotent stem cellsMesodermal lineagesActin polymerizationStem cellsActin-myosin molecular motorEmbryonic stem cellsCell-based therapiesGerm lineageCytoskeletal tensionEndodermal lineagesDifferentiation eventsEmbryoid bodiesLineagesSpontaneous differentiationIntracellular factorsModulates differentiationMolecular motorsEarly differentiationStem cell-based therapiesActin-myosin interactionCytoskeletonDifferentiationRegenerative medicineEndothelial cellsCells
2016
Lack of vimentin impairs endothelial differentiation of embryonic stem cells
Boraas L, Ahsan T. Lack of vimentin impairs endothelial differentiation of embryonic stem cells. Scientific Reports 2016, 6: 30814. PMID: 27480130, PMCID: PMC4969593, DOI: 10.1038/srep30814.Peer-Reviewed Original ResearchConceptsEmbryonic stem cellsEmbryoid bodiesKnockout embryonic stem cellsWild-type embryonic stem cellsStem cellsEndothelial phenotypeCell typesWT EBsSpecification pathwayCytoskeletal filament vimentinGene expressionSpontaneous differentiationPluripotency markersEndothelial differentiationProper functionVE-cadherinPresence of vimentinPhenotypeProtein expressionDifferentiationDecreased expressionExpressionEndothelial cellsCellsAdult mice