2008
Elevation of activated γδ T cell receptor bearing T lymphocytes in patients with autoimmune chronic liver disease
WEN L, PEAKMAN M, MIELI-VERGANI G, VERGANI D. Elevation of activated γδ T cell receptor bearing T lymphocytes in patients with autoimmune chronic liver disease. Clinical & Experimental Immunology 2008, 89: 78-82. PMID: 1385768, PMCID: PMC1554410, DOI: 10.1111/j.1365-2249.1992.tb06881.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntigens, CDAutoimmune DiseasesChildCholangitis, SclerosingFemaleFlow CytometryFluorescent Antibody TechniqueHepatitis, ChronicHistocompatibility AntigensHLA-DR AntigensHumansLeukocyte Common AntigensLiver DiseasesMaleReceptors, Antigen, T-Cell, gamma-deltaReceptors, Interleukin-2T-LymphocytesConceptsPrimary sclerosing cholangitisGroup of patientsTCR gamma deltaT cellsAI-CAHLiver diseaseHLA-DRPeripheral bloodAutoimmune chronic active hepatitisAutoimmune chronic liver diseaseMemory cell marker CD45ROActivation markers HLA-DRΓδ T cell receptorAbsolute numberAutoimmune liver diseaseChronic active hepatitisChronic liver diseaseMarkers HLA-DRGamma delta T cell receptor (TCR) heterodimerIL-2 receptorT cell receptorT cell receptor heterodimerLevels of gammaActive hepatitisSclerosing cholangitis
1997
γδ T-cell help in responses to pathogens and in the development of systemic autoimmunity
Wen L, Hayday A. γδ T-cell help in responses to pathogens and in the development of systemic autoimmunity. Immunologic Research 1997, 16: 229-241. PMID: 9379074, DOI: 10.1007/bf02786392.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesAutoimmunityHumansMiceMice, KnockoutReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesConceptsΓδ T cellsT cell helpT cellsAutoimmune diseasesΑβ T cell-deficient miceT cell-deficient miceSelf-reactive IgGPhysiologic immune responseΑβ T cellsGerminal center formationAutoantibody formationSystemic autoimmunityImmune responseGerminal centersHealthy individualsB cellsProvision of helpDiseaseMiceCenter formationEnhanced levelsSignificant levelsAutoimmunityNewbornsSymptoms
1996
T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium.
Roberts S, Smith A, West A, Wen L, Findly R, Owen M, Hayday A. T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 11774-11779. PMID: 8876213, PMCID: PMC38134, DOI: 10.1073/pnas.93.21.11774.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsCD4-Positive T-LymphocytesCoccidiosisEimeriaGastrointestinal HemorrhageIntestinal DiseasesIntestinal MucosaIntestine, SmallLymph NodesLymphocyte TransfusionMiceMice, Inbred C57BLMice, Inbred StrainsMice, KnockoutPhenotypeReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesConceptsAlpha beta T cellsBeta T cellsT cellsGamma deltaT cell antigen receptorAlpha beta T-cell responsesT cell effector functionGamma delta T-cell antigen receptorsAlpha betaT cell responsesIntestinal damageProtective immunityAutoimmune diseasesEpithelial infectionDeficient miceEffector functionsEimeria vermiformisImmune systemCell responsesIntestinal epitheliumIntracellular protozoanWidespread infectionAntigen receptorInfectionMiceγδ T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells
Pao W, Wen L, Smith A, Gulbranson-Judge A, Zheng B, Kelsoe G, MacLennan I, Owen M, Hayday A. γδ T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. Current Biology 1996, 6: 1317-1325. PMID: 8939571, DOI: 10.1016/s0960-9822(02)70718-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntibodies, ProtozoanB-LymphocytesCD4 AntigensCoccidiosisEimeriaGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorGerminal CenterImmunity, CellularImmunoglobulin GMiceMice, Mutant StrainsReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocytes, Helper-InducerConceptsGamma delta T cellsDelta T cellsT cell-B cell collaborationT cell helpT cell-deficient miceCell-deficient miceGamma delta cellsT cellsCell helpB cellsGerminal centersParasitic infectionsCell collaborationAlpha beta T cellsBeta T cellsT cell deficiencyDelta cellsDevelopment of autoimmunityAntibody levelsMycobacterial antigensCell deficiencyImmune responseAnatomical focusImmune systemAntibody specificity
1994
Lymphocyte proliferation in mice congenitally deficient in T-cell receptor alpha beta + cells.
Viney J, Dianda L, Roberts S, Wen L, Mallick C, Hayday A, Owen M. Lymphocyte proliferation in mice congenitally deficient in T-cell receptor alpha beta + cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 11948-11952. PMID: 7991563, PMCID: PMC45353, DOI: 10.1073/pnas.91.25.11948.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCells, CulturedGene ExpressionLymph NodesLymphocyte ActivationMiceMice, KnockoutPeyer's PatchesReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSpleenT-LymphocytesConceptsTCR gamma deltaTCR alpha betaGamma deltaAlpha betaT-cell receptor alpha betaT cell receptor expressionSurface activation markersAlpha mutant miceWild-type animalsActivation markersEnvironmental antigensLymphoid componentLymphocyte proliferationLymphoid organsLymphoid tissueReceptor expressionT cellsImmune responseMutant miceAbsolute numberMiceSubstantial proportionCell populationsPrimary regulatorBetaT Cell Clones Generated from Patients with Type 1 Diabetes Using Interleukin-2 Proliferate to Human Islet Antigens
Peakman M, Wen L, McNab G, Watkins P, Tan K, Vergani D. T Cell Clones Generated from Patients with Type 1 Diabetes Using Interleukin-2 Proliferate to Human Islet Antigens. Autoimmunity 1994, 17: 31-39. PMID: 8025212, DOI: 10.3109/08916939409014656.Peer-Reviewed Original ResearchMeSH KeywordsAdultAutoantigensAutoimmune DiseasesCD4 AntigensCD8 AntigensChildChild, PreschoolClone CellsDiabetes Mellitus, Type 1FemaleHumansInterleukin-2Islets of LangerhansLymphocyte ActivationMaleReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, Interleukin-2T-Lymphocyte SubsetsConceptsT cell clonesT lymphocytesIslet antigensControl subjectsAntigen specificityType 1Cell clonesT cell populationsPeripheral blood lymphocytesIL-2 receptorActivated T lymphocytesDose-dependent fashionPrediabetic periodLiver membrane preparationsPeripheral bloodAutologous APCIL-2Blood lymphocytesPatientsHuman isletsLymphocytesMembrane preparationsProliferation assaysPathogenesisAntigen