2021
Innate immunity in latent autoimmune diabetes in adults
Huang J, Pearson JA, Wong FS, Wen L, Zhou Z. Innate immunity in latent autoimmune diabetes in adults. Diabetes/Metabolism Research And Reviews 2021, 38: e3480. PMID: 34156143, PMCID: PMC8813511, DOI: 10.1002/dmrr.3480.Peer-Reviewed Original ResearchConceptsType 1 diabetesDendritic cellsImmune cellsT cellsInnate immunityPathogenesis of LADALatent autoimmune diabetesAdaptive immune cellsPancreas of patientsType 2 diabetesImmune-associated genesIslet β-cellsAutoimmune diabetesClinical featuresImmunological reasonsAutoimmune diseasesRat modelB cellsDiabetesΒ-cellsImmunityPotential rolePathogenesisLADADisease
2014
IRAK-M Deficiency Promotes the Development of Type 1 Diabetes in NOD Mice
Tan Q, Majewska-Szczepanik M, Zhang X, Szczepanik M, Zhou Z, Wong FS, Wen L. IRAK-M Deficiency Promotes the Development of Type 1 Diabetes in NOD Mice. Diabetes 2014, 63: 2761-2775. PMID: 24696448, PMCID: PMC4113073, DOI: 10.2337/db13-1504.Peer-Reviewed Original ResearchConceptsDiabetogenic T cellsNOD miceRapid progressionT cellsInterleukin-1 receptor-associated kinase MOrgan-specific autoimmune diseasesType 1 diabetes mellitusAnti-insulin autoantibodiesImmunodeficient NOD miceImpaired glucose toleranceAntigen-presenting functionNonobese diabetic (NOD) miceToll-like receptor pathwayAntigen-presenting cellsEnhanced activationType 1 diabetesInnate immune pathwaysIRAK-M deficiencyInnate immune processesInsulin-secreting pancreatic β-cellsPancreatic β-cellsSevere insulitisAutoimmune diabetesDendritic cellsDiabetes mellitus
2009
Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice
Xiao X, Ma B, Dong B, Zhao P, Tai N, Chen L, Wong FS, Wen L. Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice. Journal Of Autoimmunity 2009, 32: 85-93. PMID: 19200691, DOI: 10.1016/j.jaut.2008.12.003.Peer-Reviewed Original ResearchConceptsDiabetic NOD miceNOD miceDiabetic nephropathyDiabetic miceNon-diabetic NOD miceNon-obese diabetic (NOD) miceDuration of diabetesUrinary albumin excretionAdditional therapeutic targetsHumoral immune responseAlbumin excretionAutoimmune diabetesDendritic cellsDiabetes onsetImmune changesKidney weightIgG depositsHumoral immunityT cellsImmune responseNephropathyComplement C3Therapeutic targetB cellsImmune system
2008
Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection
MA Y, PEAKMAN M, LOBO-YEO A, WEN L, LENZI M, GÄKEN J, FARZANEH F, MIELI-VERGANI G, BIANCHI F, VERGANI D. Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection. Clinical & Experimental Immunology 2008, 97: 94-99. PMID: 8033426, PMCID: PMC1534799, DOI: 10.1111/j.1365-2249.1994.tb06585.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntibody SpecificityAutoantibodiesAutoantigensAutoimmune DiseasesB-LymphocytesChildChild, PreschoolCytochrome P-450 CYP2D6Cytochrome P-450 Enzyme SystemFemaleHepatitisHepatitis CHepatitis, ChronicHumansInfantMaleMiddle AgedMixed Function OxygenasesRecombinant Fusion ProteinsConceptsChronic hepatitis C virus (HCV) infectionHepatitis C virus infectionLKM-1 antibodiesAutoimmune hepatitisC virus infectionLKM-1HCV infectionVirus infectionCytochrome P4502D6Liver kidney microsomal antibodiesClassical autoimmune hepatitisKidney microsomal antibodyChronic HCV infectionLymphoblastoid B cell linesMicrosomal antibodiesPositive patientsLiver diseaseB cell linesHCVPatientsImmune recognitionMolecular mimicryRecombinant CYP2D6Western blotCYP2D6
2007
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice
Hu CY, Rodriguez-Pinto D, Du W, Ahuja A, Henegariu O, Wong FS, Shlomchik MJ, Wen L. Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. Journal Of Clinical Investigation 2007, 117: 3857-3867. PMID: 18060033, PMCID: PMC2096456, DOI: 10.1172/jci32405.Peer-Reviewed Original ResearchConceptsB-cell depletionCell depletionB cellsNOD miceTherapeutic B cell depletionTransgenic NOD miceRegulatory B cellsLong-term remissionExpansion of TregsOnset of diabetesType 1 diabetesReverse diabetesClinical efficacyDiabetic miceAutoimmune diseasesFrank hyperglycemiaAntigen presentationT cellsHuman CD20DiabetesTherapeutic actionMiceClinical hyperglycemiaDiseasePotential mechanisms
2000
In Vivo Evidence for the Contribution of Human Histocompatibility Leukocyte Antigen (Hla)-Dq Molecules to the Development of Diabetes
Wen L, Wong F, Tang J, Chen N, Altieri M, David C, Flavell R, Sherwin R. In Vivo Evidence for the Contribution of Human Histocompatibility Leukocyte Antigen (Hla)-Dq Molecules to the Development of Diabetes. Journal Of Experimental Medicine 2000, 191: 97-104. PMID: 10620608, PMCID: PMC2195792, DOI: 10.1084/jem.191.1.97.Peer-Reviewed Original ResearchConceptsClass II moleculesMHC class II moleculesGlutamic acid decarboxylaseRat insulin promoterSpontaneous diabetesB7-1T cellsBeta cellsMouse MHC class II moleculesTransgenic miceHuman histocompatibility leukocyte antigenHuman type 1 diabetesMajor histocompatibility complex (MHC) class II moleculesCostimulatory molecules B7-1Human MHC class II moleculesVivo evidenceHistocompatibility leukocyte antigenDevelopment of diabetesType 1 diabetesMHC class IIC57BL/6 transgenic miceMurine MHC class IIPancreatic beta cellsVivo experimental evidenceDiabetogenic role
1996
Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.
Wen L, Pao W, Wong FS, Peng Q, Craft J, Zheng B, Kelsoe G, Dianda L, Owen MJ, Hayday AC. Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. Journal Of Experimental Medicine 1996, 183: 2271-2282. PMID: 8642336, PMCID: PMC2192585, DOI: 10.1084/jem.183.5.2271.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesClone CellsFlow CytometryGerminal CenterHumansImmunoglobulin Class SwitchingImmunoglobulin EImmunoglobulin GLupus Erythematosus, SystemicLymphocyte DepletionMiceMice, Inbred NODMice, Inbred StrainsMice, KnockoutMice, SCIDReceptors, Antigen, T-Cell, alpha-betaSpleenT-LymphocytesConceptsSystemic lupus erythematosusBeta T cellsAlpha/beta T cellsGamma/delta T cellsDelta T cellsT cell helpT cellsT cell receptorCell helpT cell-mediated conditionsHuman systemic lupus erythematosusSevere combined immunodeficient (SCID) miceDevelopment of autoantibodiesCombined Immunodeficient MiceT-cell immunodeficiencyClass-switched antibodiesB cell collaborationGerminal center formationLupus erythematosusAutoantibody productionLymphoid folliclesImmunoglobulin class switchingIgE synthesisAlpha/betaCell immunodeficiency
1994
Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells
Wen L, Roberts S, Viney J, Wong F, Mallick C, Findly R, Peng Q, Craft J, Owen M, Mayday A. Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells. Nature 1994, 369: 654-658. PMID: 8208291, DOI: 10.1038/369654a0.Peer-Reviewed Original ResearchConceptsΑβ T cellsT cellsT cell antigen receptorB cell-T cell interactionsHelp of CD4Provision of cytokinesB cell hyperactivitySystemic lupus erythematosusCognate B cell-T cell interactionT cell functionGeneralized autoimmunityLupus erythematosusTransplant rejectionIgE secretionImmunoglobulin synthesisB cellsIgG3 secretionAntigen receptorCD4AutoimmunityMiceSecretionAntibodiesCellsErythematosus
1990
T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis
Wen L, Peakman M, Lobo-Yeo A, Vergani D, Mowat A, Mieli-Vergani, McFarlane B. T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis. The Lancet 1990, 336: 1527-1530. PMID: 1979365, DOI: 10.1016/0140-6736(90)93306-a.Peer-Reviewed Original ResearchConceptsAutoimmune chronic active hepatitisChronic active hepatitisActive hepatitisPeripheral bloodT lymphocytesAutologous B lymphocytesLiver membrane antigensT cell clonesAsialoglycoprotein receptorActivated T lymphocytesLiver cell membraneSpecific autoantibodiesAutoimmune attackImmune attackHepatocyte damageHepatitisB lymphocytesLymphocytesBloodLipoprotein complexAutoantibodiesPatientsCell membraneAntigenClones